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基于活性的凝血酶检测探针中绿色发光的 4,5-二氨基萘酰亚胺

Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin.

机构信息

Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland.

Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wybrezeże Wyspiańskiego 27, Wrocław 50-370, Poland.

出版信息

Org Lett. 2022 Aug 5;24(30):5602-5607. doi: 10.1021/acs.orglett.2c02320. Epub 2022 Jul 21.

DOI:10.1021/acs.orglett.2c02320
PMID:35863755
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9361357/
Abstract

The natures of electron-donating groups as well as the bridge between them determine the fate of substituted 1,8-naphthalimide molecules in the excited state. An activity-based probe constructed from a selective peptide sequence, a reactive warhead, and the brightest green-emitting fluorophore displays impressive performance for thrombin protease detection in a newly constructed series of 1,8-naphthalimides.

摘要

供电子基团的性质以及它们之间的连接桥决定了取代 1,8-萘酰亚胺分子在激发态下的命运。从一个选择性的肽序列、一个反应性的弹头和最亮的绿色荧光团构建的一种基于活性的探针，在新构建的一系列 1,8-萘酰亚胺中显示出对凝血酶蛋白酶检测的优异性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5770/9361357/a01814cb068e/ol2c02320_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5770/9361357/b6ac8e57b6d8/ol2c02320_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5770/9361357/cc8168e5173a/ol2c02320_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5770/9361357/fc7c1ecf71eb/ol2c02320_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5770/9361357/a01814cb068e/ol2c02320_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5770/9361357/b6ac8e57b6d8/ol2c02320_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5770/9361357/cc8168e5173a/ol2c02320_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5770/9361357/fc7c1ecf71eb/ol2c02320_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5770/9361357/a01814cb068e/ol2c02320_0004.jpg

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2
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Res Pract Thromb Haemost. 2022 May 25;6(4):e12728. doi: 10.1002/rth2.12728. eCollection 2022 May.
3
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Metab Brain Dis. 2021 Mar;36(3):407-420. doi: 10.1007/s11011-020-00652-w. Epub 2021 Jan 7.
4
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Nat Chem Biol. 2021 Feb;17(2):222-228. doi: 10.1038/s41589-020-00689-z. Epub 2020 Oct 22.
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J Am Chem Soc. 2020 Sep 30;142(39):16704-16715. doi: 10.1021/jacs.0c06762. Epub 2020 Sep 15.
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