State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Org Lett. 2010 Jul 16;12(14):3196-9. doi: 10.1021/ol1011289.
(+)-Linderaspirone A and (-)-linderaspirone A, a pair of natural windmill-shaped enantiomers, were isolated from the traditional Chinese medicine plant Lindera aggregate by HPLC using a chiral column, achieving over 98% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra, crystal X-ray diffraction, and calculation of the optical rotations (OR). They have an unprecedented carbon skeleton and showed significant activity against glucosamine-induced insulin resistance.
（+）-Linderaspirone A 和（-）-linderaspirone A 是一对天然风车型对映异构体，从传统中药黄肉楠属植物中通过 HPLC 用手性柱分离得到，ee 值超过 98%。根据 NMR 谱、晶体 X 射线衍射和旋光度（OR）计算的综合分析，确定了它们的结构和绝对构型。它们具有前所未有的碳骨架，对葡萄糖胺诱导的胰岛素抵抗表现出显著的活性。
