Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research (CSIR), Bhavnagar, Gujarat, India.
Drug Dev Ind Pharm. 2010 Sep;36(9):1046-53. doi: 10.3109/03639041003642073.
The objective of this work was to illustrate the suitability of montmorillonite (MMT) as a drug delivery carrier, by developing a new clay-drug composite of ranitidine hydrochloride (RT) intercalated in MMT.
The MMT-RT composite was prepared by ion-exchange process. X-ray diffraction and Fourier transform infrared spectra were employed to confirm the intercalation of RT in the MMT interlayers. The prepared MMT-RT hybrid was coated with cationic polymer Eudragit E-100 by oil-in-water solvent evaporation method. The release processes of RT from MMT-RT and MMT-RT/Eudragit E-100 were monitored under in vitro condition in the gastric fluid.
X-ray diffraction and Fourier transform infrared spectra analysis indicated the intercalation of RT molecules within the clay lattice. The in vitro release studies showed that MMT-RT released RT in a controlled manner. In the case of MMT-RT/Eudragit E-100, both the release rate and the release percentages noticeably increased in the presence of Eudragit E-100, because of its effective exchange with intercalated RT molecules. The release kinetics followed parabolic diffusion mechanism.
MMT has great potential as a drug delivery carrier with various scenarios. The dosage of the MMT-RT/Eudragit E-100 can be in the tablet form. The hybrid material and polymer-coated hybrids are microparticles.
本工作旨在通过制备插层有盐酸雷尼替丁（RT）的新型粘土-药物复合材料，说明蒙脱石（MMT）作为药物载体的适用性。
通过离子交换法制备 MMT-RT 复合材料。采用 X 射线衍射和傅里叶变换红外光谱来确认 RT 插层进入 MMT 层间。通过油包水溶剂蒸发法，用阳离子聚合物 Eudragit E-100 对制备的 MMT-RT 杂化物进行涂层。在体外条件下，在胃液中监测 RT 从 MMT-RT 和 MMT-RT/Eudragit E-100 中的释放过程。
X 射线衍射和傅里叶变换红外光谱分析表明 RT 分子插层进入粘土晶格。体外释放研究表明 MMT-RT 以控制方式释放 RT。对于 MMT-RT/Eudragit E-100，由于与插层 RT 分子的有效交换，Eudragit E-100 的存在明显增加了释放速率和释放百分比。释放动力学遵循抛物线扩散机制。
MMT 作为一种具有多种应用场景的药物载体具有很大的潜力。MMT-RT/Eudragit E-100 的剂量可以制成片剂形式。混合材料和聚合物涂层的混合材料是微粒。
