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骨关节炎患者血清 nesfatin-1 水平升高及其与 BMI、hsCRP 和 IL-18 的关系。

Increased serum levels and chondrocyte expression of nesfatin-1 in patients with osteoarthritis and its relation with BMI, hsCRP, and IL-18.

机构信息

Department of Orthopedics Surgery, The Second Hospital of Medical College, Zhejiang University, Hangzhou 310000, China.

出版信息

Mediators Inflamm. 2013;2013:631251. doi: 10.1155/2013/631251. Epub 2013 Oct 23.

DOI:10.1155/2013/631251
PMID:24259949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3821943/
Abstract

BACKGROUND

Adipokines have been proved to relate with osteoarthritis (OA). As a recently discovered adipokine, nesfatin-1 relationship with OA has not been reported.

AIM

To determine the levels of nesfatin-1 in serum and synovial fluid (SF) from patients with and without OA; to examine the correlation between nesfatin-1 levels and high sensitivity C-reactive protein (hsCRP), Type IIA Collagen N Propeptide (PIIANP), and IL-18 (interleukin-18) levels in serum or synovial fluid.

METHODS

Serum and SF were collected from knee OA patients and healthy persons, respectively. Five articular tissues were obtained during TKR for immunohistochemistry (IHC). Nesfatin-1 levels, hsCRP, PIIANP, and IL-18 in serum and SF were analyzed by enzyme-linked immunosorbent assay (ELISA).

RESULTS

Nesfatin-1 gene was expressed in OA-affected articular cartilage. OA serum contained significantly higher levels of nesfatin-1, as compared to serum from healthy controls (P < 0.05), and nesfatin-1 levels in OA serum exceeded those in paired SF samples (P < 0.001). Significant correlation was found between serum nesfatin-1 and hsCRP levels in OA patients (r = 0.593, P = 0.00005) and also synovial nesfatin-1 and IL-18 levels (r = 0.560, P = 0.0017).

CONCLUSION

Nesfatin-1 is present in articular tissues and may contribute to the physiopathologic changes in OA. Nesfatin-1, accompanied with hsCRP and IL-18, could be new molecular makers to speculate OA progression.

摘要

背景

脂肪因子已被证明与骨关节炎（OA）有关。作为一种新发现的脂肪因子，nesfatin-1 与 OA 的关系尚未报道。

目的

确定 OA 患者和非 OA 患者血清和滑液（SF）中 nesfatin-1 的水平；检查血清和滑液中 nesfatin-1 水平与高敏 C 反应蛋白（hsCRP）、II 型胶原 N 端前肽（PIIANP）和白细胞介素-18（IL-18）水平之间的相关性。

方法

分别收集膝关节 OA 患者和健康人的血清和 SF。在 TKR 期间，对 5 个关节组织进行免疫组织化学（IHC）检测。通过酶联免疫吸附试验（ELISA）分析血清和 SF 中的 nesfatin-1 水平、hsCRP、PIIANP 和 IL-18。

结果

OA 关节软骨中表达了 nesfatin-1 基因。OA 血清中 nesfatin-1 水平明显高于健康对照组（P < 0.05），且 OA 血清中 nesfatin-1 水平高于配对 SF 样本（P < 0.001）。OA 患者血清 nesfatin-1 与 hsCRP 水平呈显著相关（r = 0.593，P = 0.00005），滑膜 nesfatin-1 与 IL-18 水平也呈显著相关（r = 0.560，P = 0.0017）。

结论

nesfatin-1 存在于关节组织中，可能参与 OA 的病理生理变化。nesfatin-1 与 hsCRP 和 IL-18 一起可能成为推测 OA 进展的新分子标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbd/3821943/8de16a4c6fa9/MI2013-631251.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbd/3821943/bfca80bcc481/MI2013-631251.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbd/3821943/daf87fdca8a2/MI2013-631251.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbd/3821943/841aadedf363/MI2013-631251.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbd/3821943/b1ae168c970a/MI2013-631251.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbd/3821943/c2fdd71246b6/MI2013-631251.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbd/3821943/8de16a4c6fa9/MI2013-631251.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbd/3821943/bfca80bcc481/MI2013-631251.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbd/3821943/daf87fdca8a2/MI2013-631251.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbd/3821943/841aadedf363/MI2013-631251.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbd/3821943/b1ae168c970a/MI2013-631251.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbd/3821943/c2fdd71246b6/MI2013-631251.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afbd/3821943/8de16a4c6fa9/MI2013-631251.006.jpg

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