Dermatology Clinic, TDV 29 Mayis Private Ankara Hospital, Ankara, Turkey.
Br J Dermatol. 2010 Oct;163(4):719-25. doi: 10.1111/j.1365-2133.2010.09894.x.
Rosacea has a major psychosocial impact on a patient's life.
To determine the impact of rosacea on patient quality of life, the relationship of quality of life scores to clinical and demographic variables, and the change in quality of life following various treatments.
Patients' demographic and clinical characteristics were recorded at their initial examination and their response to treatment and side-effects were recorded additionally at their follow-up examination. Rosacea severity was scored for each of four signs from 0 to 3. Patients were requested to complete Dermatology Life Quality Index (DLQI) questionnaires.
A total of 308 patients took part in this study. Mean ± SD DLQI total score at the initial visit was 6·93 ± 5·18 and was related to patients' age, sex, age at disease onset, subjective symptoms, triggering factors, previous treatments, rosacea severity scores and patients' self-assessment of ease of living with rosacea. Of these 308 patients, 164 completed the DLQI following treatment. Mean ± SD post-treatment DLQI score was 4·36 ± 4·82. Post-treatment scores were also related to sex, type of treatment modality, development of side-effects, improvement of rosacea, rosacea severity scores and patients' self-reported ease of living with rosacea. Topical metronidazole, oral tetracycline and oral isotretinoin were observed to reduce signs and symptoms of rosacea and DLQI scores significantly at this repeat examination.
Rosacea affects patients' lives to a moderate extent, and this can be assessed by using DLQI. DLQI is also sensitive to quality of life changes brought about by treatment of rosacea. As a preliminary result we can say that topical metronidazole, oral tetracycline and oral isotretinoin seem to improve quality of life of patients by improving lesions of rosacea more efficiently than other therapeutic agents.
酒渣鼻对患者的生活有重大的心理社会影响。
确定酒渣鼻对患者生活质量的影响、生活质量评分与临床和人口统计学变量的关系，以及各种治疗方法对生活质量的变化。
在初次检查时记录患者的人口统计学和临床特征，并在随访检查时另外记录他们的治疗反应和副作用。对四个体征中的每一个从 0 到 3 进行酒渣鼻严重程度评分。要求患者完成皮肤病生活质量指数（DLQI）问卷。
共有 308 名患者参与了这项研究。初次就诊时的平均±SD DLQI 总分是 6.93±5.18，与患者的年龄、性别、发病年龄、主观症状、诱发因素、既往治疗、酒渣鼻严重程度评分和患者对酒渣鼻生活舒适度的自我评估有关。在这 308 名患者中，有 164 名在治疗后完成了 DLQI。治疗后的平均±SD DLQI 评分是 4.36±4.82。治疗后的评分也与性别、治疗方式类型、副作用的发展、酒渣鼻的改善、酒渣鼻严重程度评分和患者对酒渣鼻生活舒适度的自我报告有关。局部甲硝唑、口服四环素和口服异维 A 酸在这次复诊中被观察到能显著减轻酒渣鼻的体征和症状，并降低 DLQI 评分。
酒渣鼻在一定程度上影响了患者的生活，这可以通过 DLQI 来评估。DLQI 也对酒渣鼻治疗带来的生活质量变化敏感。作为初步结果，我们可以说局部甲硝唑、口服四环素和口服异维 A 酸似乎比其他治疗药物更有效地改善了酒渣鼻的病变，从而提高了患者的生活质量。
