酒渣鼻患者的临床人口统计学特征、加重因素、合并症及生活质量：一项巴西多中心研究（GBPER：巴西酒渣鼻研究与研究小组）
Clinical-demographic profile, aggravating factors, comorbidities, and quality of life in patients with Rosacea: a Brazilian multicenter study (GBPER: Brazilian Research and Studies Group on Rosacea).
作者信息
Bonamigo Renan Rangel, Barea Paula, Peruzzo Juliano, Boza Juliana, Miot Hélio Amante, Bagatin Edileia, Almeida Luiz Maurício Costa, Milano Giovanni Indelicato, Lima Carla Wanderley Gayoso de, Vidal Linácia Freitas, Picosse Fabíola Rosa, Afonso Bruna Manuella de Figueiredo, Oliveira Clivia Maria Moraes de
机构信息
Service of Dermatology, Hospital de Clínicas de Porto Alegre, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Service of Dermatology, Santa Casa de Porto Alegre, Porto Alegre, RS, Brazil.
Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
出版信息
An Bras Dermatol. 2025 Jul 11;100(5):501160. doi: 10.1016/j.abd.2025.501160.
BACKGROUND
Rosacea is the most prevalent chronic vascular-inflammatory dermatosis of the face. Its pathogenesis includes genetic and environmental factors, neurovascular alterations, and innate immunity. Many triggering and aggravating factors, as well as systemic comorbidities, have been associated with the disease, but there are few studies on its epidemiology in Brazil.
OBJECTIVES
To describe the profile of patients with rosacea treated at referral centers, as well as to investigate the presence of comorbidities, dietary aspects, worsening factors, and quality of life.
METHODS
Cross-sectional and multicenter Brazilian study. Clinical and demographic data, disease severity, triggering and/or aggravating factors, diet, comorbidities, and impact on quality of life were evaluated.
RESULTS
258 patients were included, predominantly women, between 35 and 65 years old and phototypes III, IV and II. The clinical picture ranged from mild to moderate in 89% of cases and quality of life was reasonable to slightly affected in 58% of cases. Aggravating factors for rosacea were reported by 96% of patients, with climate exposure, alcoholic beverages, and emotional changes being the most frequent. Among the foods mentioned as aggravating factors (28%), pepper, other condiments and hot beverages were the most frequently reported. Comorbidities were reported by 89% of the participants, with emphasis on endocrine (48%), psychiatric (35%), cardiovascular (31%) and gastrointestinal (28%) diseases.
STUDY LIMITATIONS
Uncontrolled study, including patients undergoing dermatological treatment.
CONCLUSIONS
This study establishes that the profile of Brazilian patients with rosacea corroborates that described in the literature, with the presence of the disease in higher phototypes being relevant. Pepper and other condiments and hot beverages were important aggravating factors, and the presence of various comorbidities was reported by most of the patients.
背景
酒渣鼻是面部最常见的慢性血管炎性皮肤病。其发病机制包括遗传和环境因素、神经血管改变以及先天免疫。许多诱发和加重因素以及全身性合并症都与该疾病有关，但巴西关于其流行病学的研究较少。
目的
描述在转诊中心接受治疗的酒渣鼻患者的特征，以及调查合并症的存在情况、饮食方面、加重因素和生活质量。
方法
巴西的一项横断面多中心研究。评估了临床和人口统计学数据、疾病严重程度、诱发和/或加重因素、饮食、合并症以及对生活质量的影响。
结果
纳入了258例患者，主要为35至65岁的女性，皮肤类型为III型、IV型和II型。89%的病例临床表现为轻度至中度，58%的病例生活质量受到合理至轻微的影响。96%的患者报告了酒渣鼻的加重因素，其中暴露于气候、酒精饮料和情绪变化最为常见。在被提及为加重因素的食物中（28%），辣椒、其他调味品和热饮是报告最多的。89%的参与者报告了合并症，其中以内分泌疾病（48%）、精神疾病（35%）、心血管疾病（31%）和胃肠道疾病（28%）最为突出。
研究局限性
未设对照研究，纳入了正在接受皮肤科治疗的患者。
结论
本研究表明，巴西酒渣鼻患者的特征与文献中描述的相符，较高皮肤类型中该疾病的存在具有相关性。辣椒、其他调味品和热饮是重要的加重因素，大多数患者报告存在各种合并症。
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