Department of Oral Health and Welfare, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Gerodontology. 2011 Jun;28(2):116-20. doi: 10.1111/j.1741-2358.2009.00358.x. Epub 2010 Jun 2.
To investigate medications that are related to volume of saliva in the elderly.
In the elderly, many cases of mouth dryness may represent side effects of medication.
The volume of unstimulated saliva was measured for 30 s (cotton roll test), and with stimulation for 3 min (gum test) in 368 subjects 79-80 years old (177 men, 191 women). Medications were investigated using subject's medication notebooks.
Mean volumes of unstimulated and stimulated saliva were 0.14±0.13 and 4.30±2.54 ml respectively. Significant differences were seen between gender and mean volume of saliva. The volume of unstimulated saliva was 0.16±0.15 ml for men and 0.11±0.10 ml for women. The volume of stimulated saliva was 4.99±2.67 ml for men and 3.67±2.25 ml for women. The percentage of subjects taking medication was 64.7% (238/368). Mean number of medications was 2.08±2.26, with no significant difference with gender (2.01±2.37 for men, 2.16±2.16 for women). In a stepwise multiple regression analysis with volume of saliva as the objective variable and number of drugs by category as explanatory variables, significant explanatory variables in addition to gender and number of medications were blood-coagulating agents, Ca antagonists and peptic ulcer drugs for volume of unstimulated saliva, and diabetes medications and peptic ulcer drugs for volume of stimulated saliva.
These findings suggest that differences exist between gender in volume of saliva for elderly individuals, and that the volume of saliva is affected by the number and type of medications.
调查与老年人唾液量相关的药物。
在老年人中，许多口干的情况可能代表药物的副作用。
对 368 名 79-80 岁的受试者（177 名男性，191 名女性）进行了 30 秒（棉卷试验）和 3 分钟（牙龈试验）的非刺激性唾液量测量，并使用受试者的用药笔记本调查了药物。
未刺激和刺激的唾液平均体积分别为 0.14±0.13 和 4.30±2.54ml。性别和唾液平均体积之间存在显著差异。男性未刺激唾液量为 0.16±0.15ml，女性为 0.11±0.10ml。刺激唾液量为男性 4.99±2.67ml，女性 3.67±2.25ml。服用药物的受试者比例为 64.7%（238/368）。平均用药数为 2.08±2.26，与性别无显著差异（男性 2.01±2.37，女性 2.16±2.16）。在以唾液量为因变量、药物类别数为自变量的逐步多元回归分析中，除性别和用药数外，有统计学意义的解释变量还有抗凝剂、钙拮抗剂和消化性溃疡药物与未刺激唾液量相关，糖尿病药物和消化性溃疡药物与刺激唾液量相关。
这些发现表明，老年人群体的唾液量存在性别差异，且唾液量受药物种类和数量的影响。
