Department of Pediatrics, University College of Medical Sciences, University of Delhi, New Delhi, India.
Acta Paediatr. 2010 Nov;99(11):1671-4. doi: 10.1111/j.1651-2227.2010.01912.x. Epub 2010 Jun 25.
(i) To measure 25-OH vitamin D levels in term infants at 10 weeks and 6 months and to correlate with maternal vitamin D levels at 10-week postpartum (ii) To evaluate infants at 6 months for rickets.
A total of 179 exclusively breastfed infant-mother pairs 96 appropriate-for-gestational age (Group 1) and 83 small- for- gestational age infants (Group 2) recruited at 10 weeks. At 6 months, 52 in group 1 and 45 in group 2 were evaluated. Venous blood sample were collected at 10 weeks and 6 months in infants and at 10 weeks in mothers for calcium, phosphorus, alkaline phosphatase and 25-OH vitamin D estimation.
Mean 25-OH vitamin D levels of infants (n = 97) were 11.55 ± 7.17 ng/mL at 10 weeks and 16.96 ± 13.33 ng/mL at 6 months (p < 0.001). Mean vitamin D levels of infants in group 1 and group 2 did not differ at recruitment and 6 months (p > 0.05)). Maternal vitamin D levels in group 1 and group 2 were 8.89 ± 5.97 and 9.87 ± 6.44 ng/mL, respectively (p = 0.44). Significant correlation was observed between 25-OH vitamin D of infants and mothers (p < 0.05). At 10 weeks, 55.67% infants, 70% mothers and at 6 months, 44.33% infants had vitamin D < 11 ng/mL. At 6 months, 16.49% infants developed rickets.
Exclusively breastfed infants and their mothers are Vitamin D deficient, hence the need to improve vitamin D status.
（i）测量 10 周和 6 个月龄足月婴儿的 25-羟维生素 D 水平，并与产后 10 周时的产妇维生素 D 水平相关联；（ii）在 6 个月时评估婴儿是否患有佝偻病。
共纳入 179 对纯母乳喂养的母婴，96 例为适于胎龄儿（第 1 组），83 例为小于胎龄儿（第 2 组），于 10 周时入组。6 个月时，第 1 组中有 52 例，第 2 组中有 45 例接受评估。于婴儿 10 周和 6 个月以及母亲 10 周时采集静脉血样，以测定钙、磷、碱性磷酸酶和 25-羟维生素 D。
10 周时，97 例婴儿的平均 25-羟维生素 D 水平为 11.55 ± 7.17ng/mL，6 个月时为 16.96 ± 13.33ng/mL（p<0.001）。第 1 组和第 2 组婴儿在招募时和 6 个月时的平均维生素 D 水平无差异（p>0.05）。第 1 组和第 2 组产妇的维生素 D 水平分别为 8.89 ± 5.97ng/mL 和 9.87 ± 6.44ng/mL（p=0.44）。婴儿和母亲的 25-羟维生素 D 水平呈显著相关（p<0.05）。10 周时，55.67%婴儿、70%母亲和 6 个月时，44.33%婴儿的维生素 D<11ng/mL。6 个月时，16.49%婴儿出现佝偻病。
纯母乳喂养的婴儿及其母亲存在维生素 D 缺乏，因此需要改善维生素 D 状况。
