Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
Australas J Dermatol. 2010 May;51(2):131-4. doi: 10.1111/j.1440-0960.2009.00596.x.
We herein report three cases of poroma, which showed sebaceous differentiation. The patients were two men and one woman, and the involved sites were the thigh, head and back. In all three cases, histopathological examination revealed anastomosing nests consisting of poroid cells proliferating into the dermis. Tubular structures lined by eosinophilic cuticular cells were scattered in the tumour nests. Furthermore, aggregations of mature sebocytes with vacuolated cytoplasm were also observed forming clusters, or intermingled with the poroma cells. Focal calcification was found within the nests in two cases. Sebaceous component were recognized in the presented three cases among the 62 cases (4.8%) examined in our department within the past 10 years. We also include a review of the 31 reported cases of poroma with sebaceous differentiation. None of them occurred in acral regions, where typical eccrine poromas predominate. The majority of cases were benign. This review indicates that some poromas may show sebaceous differentiation and be of apocrine lineage.
我们在此报告三例具有皮脂腺分化的汗管瘤。这三例患者为两男一女，发病部位分别为大腿、头部和背部。所有三例的组织病理学检查均显示，由向真皮内增生的汗管瘤细胞组成的吻合性巢状结构。肿瘤巢内散布有被嗜酸性角质细胞包绕的管状结构。此外，还可见到成熟的皮脂腺细胞聚集，形成小团块，或与汗管瘤细胞混合存在。两例肿瘤巢内可见灶状钙化。在过去 10 年我们科室检查的 62 例（4.8%）汗管瘤中，有 3 例（4.8%）可见皮脂腺分化。我们还回顾了 31 例具有皮脂腺分化的汗管瘤病例。这些病例均未发生于肢端部位，肢端部位以典型的小汗腺汗管瘤为主。大多数病例为良性。这一回顾性研究表明，部分汗管瘤可能具有皮脂腺分化，并来自于顶泌汗腺。
