Department of Nephrology, Sanatorio Allende, Cordoba, Argentina.
J Clin Hypertens (Greenwich). 2010 May;12(5):350-6. doi: 10.1111/j.1751-7176.2010.00266.x.
The study of genes and mechanisms associated with hypertension is hampered by the heterogeneity of hypertensive patients. Refining the definition of hypertension is a potential means of improving the clarity of mechanistic studies, but the lack of intermediate phenotypes hinders the assessment of causal relationships. Looking at younger individuals and hemodynamic subsets of hypertension is one such refinement. The authors argue that the separate analysis of patients with isolated diastolic hypertension, predominantly diastolic hypertension, and isolated systolic hypertension in the young in combination with common biomarkers may be an initial step to decrease heterogeneity within patient subsets, thus providing new avenues for genetic and pathophysiological studies.
与高血压相关的基因和机制研究受到高血压患者异质性的阻碍。细化高血压的定义是提高机制研究清晰度的一种潜在手段，但中间表型的缺乏阻碍了因果关系的评估。观察年轻个体和高血压的血流动力学亚组就是这样一种细化。作者认为，对年轻患者中孤立性舒张期高血压、主要是舒张期高血压和单纯收缩期高血压患者进行单独分析，并结合常见生物标志物进行分析，可能是减少患者亚组内异质性的初始步骤，从而为遗传和病理生理学研究提供新途径。
