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在单纯收缩期高血压和单纯舒张期高血压中选择降压药物：ALLHAT 试验的二次分析。

Choice of antihypertensive agent in isolated systolic hypertension and isolated diastolic hypertension: A secondary analysis of the ALLHAT trial.

机构信息

Department of Internal Medicine, Yale School of Medicine, New Haven, CT.

Department of Internal Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH.

出版信息

Am Heart J. 2022 Dec;254:30-34. doi: 10.1016/j.ahj.2022.07.006. Epub 2022 Aug 4.

DOI:10.1016/j.ahj.2022.07.006
PMID:35932912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10908340/
Abstract

Despite broad treatment recommendations, there are limited published reports comparing the efficacy of different antihypertensive agents in patients with isolated systolic hypertension or isolated diastolic hypertension. This study was a secondary analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. We compared the use of chlorthalidone, amlodipine, or lisinopril on the primary outcome of combined coronary heart disease, stroke, or all-cause mortality in patients with isolated systolic hypertension or isolated diastolic hypertension.

摘要

尽管有广泛的治疗建议，但在单纯收缩期高血压或单纯舒张期高血压患者中，比较不同降压药物疗效的已发表报告有限。本研究是对抗高血压和降脂治疗预防心脏病发作试验的二次分析。我们比较了氯噻酮、氨氯地平或赖诺普利在单纯收缩期高血压或单纯舒张期高血压患者的主要复合终点（冠心病、卒中和全因死亡率）上的应用。

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Am Heart J. 2022 Dec;254:30-34. doi: 10.1016/j.ahj.2022.07.006. Epub 2022 Aug 4.
2
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本文引用的文献

1
Isolated Diastolic Hypertension and Risk of Cardiovascular Events: A Systematic Review and Meta-Analysis of Cohort Studies With 489,814 Participants.单纯舒张期高血压与心血管事件风险：对489,814名参与者的队列研究进行的系统评价和荟萃分析
Front Cardiovasc Med. 2022 Jan 5;8:810105. doi: 10.3389/fcvm.2021.810105. eCollection 2021.
2
Monotherapy treatment with chlorthalidone or amlodipine in the systolic blood pressure intervention trial (SPRINT).氨氯地平或氯噻酮单药治疗收缩压干预试验（SPRINT）。
J Clin Hypertens (Greenwich). 2021 Jul;23(7):1335-1343. doi: 10.1111/jch.14296. Epub 2021 Jun 2.
3
Comparison of Cardiovascular and Safety Outcomes of Chlorthalidone vs Hydrochlorothiazide to Treat Hypertension.比较氯噻酮与氢氯噻嗪治疗高血压的心血管和安全性结局。
JAMA Intern Med. 2020 Apr 1;180(4):542-551. doi: 10.1001/jamainternmed.2019.7454.
4
2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.2017美国心脏病学会/美国心脏协会/美国医师协会/美国心脏病学学会/美国预防医学学院/美国老年病学会/美国药学协会/美国血液学会/美国预防医学学会/美国医学协会/美国初级保健医师学会成人高血压预防、检测、评估和管理指南：美国心脏病学会/美国心脏协会临床实践指南工作组报告
J Am Coll Cardiol. 2018 May 15;71(19):e127-e248. doi: 10.1016/j.jacc.2017.11.006. Epub 2017 Nov 13.
5
A Randomized Trial of Intensive versus Standard Blood-Pressure Control.强化与标准血压控制的随机试验
N Engl J Med. 2015 Nov 26;373(22):2103-16. doi: 10.1056/NEJMoa1511939. Epub 2015 Nov 9.
6
Stroke outcomes among participants randomized to chlorthalidone, amlodipine or lisinopril in ALLHAT.在抗高血压和降脂治疗预防心脏病发作试验（ALLHAT）中，随机接受氯噻酮、氨氯地平或赖诺普利治疗的参与者的中风结局。
J Am Soc Hypertens. 2014 Nov;8(11):808-19. doi: 10.1016/j.jash.2014.08.003. Epub 2014 Aug 19.
7
Hypothesis: it is time to reconsider phenotypes in hypertension.假说：现在是时候重新考虑高血压中的表型了。
J Clin Hypertens (Greenwich). 2010 May;12(5):350-6. doi: 10.1111/j.1751-7176.2010.00266.x.
8
Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adults.每搏输出量增加和主动脉僵硬度增加导致年轻成年人单纯收缩期高血压。
Hypertension. 2005 Jul;46(1):221-6. doi: 10.1161/01.HYP.0000165310.84801.e0.
9
Cardiovascular risk reduction in hypertensive black patients with left ventricular hypertrophy: the LIFE study.高血压合并左心室肥厚黑人患者心血管风险降低：LIFE研究
J Am Coll Cardiol. 2004 Mar 17;43(6):1047-55. doi: 10.1016/j.jacc.2003.11.029.
10
Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.全国高血压防治联合委员会第七次报告：预防、检测、评估及治疗
Hypertension. 2003 Dec;42(6):1206-52. doi: 10.1161/01.HYP.0000107251.49515.c2. Epub 2003 Dec 1.