瑞典人群、猪和野猪中戊型肝炎病毒的分子流行病学研究。

Molecular epidemiology of hepatitis E virus in humans, pigs and wild boars in Sweden.

机构信息

Department of Virology, Immunobiology and Parasitology, Statens Veterinärmedicinska Anstalt & Department of Biomedicine and Veterinary Public Health, The Swedish University of Agricultural Sciences, Uppsala, Sweden.

出版信息

Epidemiol Infect. 2011 Mar;139(3):361-71. doi: 10.1017/S0950268810001342. Epub 2010 Jun 14.

DOI:10.1017/S0950268810001342

PMID:20546635

Abstract

Hepatitis E infections in humans are usually acquired in endemic countries in Asia or Africa. In Sweden 17 cases infected in Europe, between 1993 and 2009, were identified. All had clinical hepatitis E with unknown source of infection. Hepatitis E virus (HEV) was identified in faecal samples from 63 piglets in 12 pig farms in Sweden. HEV was also identified in blood from 13 out of 159 investigated Swedish wild boars from nine counties. Partial HEV genomes from humans, pigs and wild boars were sequenced and compared by phylogeny. The results showed close relatedness between HEV strains from piglets from the same farm and from wild boars from the same county. HEV strains from humans showed relatedness with strains from pigs and wild boars from the same county. This study showed that HEV strains form geographical clusters in the phylogenetic tree. The methods used in this study may thus be used for tracing the origin of an infecting strain. Furthermore, this study indicated that there are endemic sources of human HEV infections in Sweden.

摘要

人感染戊型肝炎病毒通常发生在亚洲或非洲的流行国家。1993 年至 2009 年期间，在瑞典发现了 17 例在欧洲感染的病例。所有病例均表现为临床戊型肝炎，感染源未知。从瑞典 12 个养猪场的 63 头仔猪的粪便样本中鉴定出戊型肝炎病毒（HEV）。还从瑞典 9 个郡的 159 头野猪的血液中鉴定出 13 头野猪携带 HEV。对来自人类、猪和野猪的部分 HEV 基因组进行了测序，并通过系统发生进行了比较。结果表明，来自同一农场仔猪的 HEV 株与来自同一县野猪的 HEV 株密切相关。来自人类的 HEV 株与来自同一县的猪和野猪的株具有相关性。本研究表明，HEV 株在系统发育树中形成地理簇。因此，本研究中使用的方法可用于追踪感染株的来源。此外，本研究表明，瑞典存在人感染戊型肝炎病毒的地方性来源。