Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
Phytochemistry. 2010 Aug;71(11-12):1387-94. doi: 10.1016/j.phytochem.2010.04.023. Epub 2010 May 22.
Cembrane-type diterpenoids, 13,18,20-epi-iso-chandonanthone (1) and (8E)-4alpha-acetoxy-12alpha,13alpha-epoxycembra-1(15),8-diene (2), two fusicoccane-type diterpenoids, fusicoauritone 6alpha-methyl ether (3) and 6beta,10beta-epoxy-5beta-hydroxyfusicocc-2-ene (4) and a zierane sesquiterpene gamma-lactone, chandolide (5) were isolated from the Tahitian liverwort Chandonanthus hirtellus (Web.) Mitt., together with eight known diterpenoids, chandonanthine (6), fusicogigantone A (7), fusicogigantone B (8), fusicogigantepoxide (9), anadensin (10), fusicoauritone (11), ent-verticillol (12) and ent-epi-verticillol (13). Their structures were established by a combination of extensive NMR spectroscopy and/or X-ray crystallographic analyses. Compounds 1, 5 and 10 showed weak cytotoxic activity against HL-60. Compound 3 also indicated weak cytotoxic activity against KB cell lines.
从大溪地肝地钱（Chandonanthus hirtellus）（Web.）Mitt. 中分离得到了 13,18,20-表异香茶菜酮（1）和（8E）-4α-乙酰氧基-12α,13α-环氧贝壳杉-1（15）,8-二烯（2），两种伏康烷型二萜，伏康醇 6α-甲醚（3）和 6β,10β-环氧-5β-羟基伏康-2-烯（4），以及一种紫堇烷倍半萜 γ-内酯，香茶菜内酯（5），此外，还分离得到了 8 种已知的二萜，香茶菜碱（6）、伏康巨酮 A（7）、伏康巨酮 B（8）、伏康巨酮氧化物（9）、阿那地辛（10）、伏康醇（11）、ent-verticillol（12）和 ent-epi-verticillol（13）。通过广泛的 NMR 光谱和/或 X 射线晶体学分析，确定了它们的结构。化合物 1、5 和 10 对 HL-60 具有较弱的细胞毒性，化合物 3 对 KB 细胞系也具有较弱的细胞毒性。
Zotero 插件