一种从婆罗洲地钱毛枝钱苔中分离得到的新型贝壳杉烷型二萜类化合物。

A new cembrane-type diterpenoid from Bornean liverwort Chandonanthus hirtellus.

作者信息

Ng Shean-Yeaw, Kamada Takashi, Suleiman Monica, Vairappan Charles S

机构信息

a Laboratory of Natural Products Chemistry , Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah , Kota Kinabalu 88400 , Malaysia.

b Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah , Kota Kinabalu 88400 , Malaysia.

出版信息

J Asian Nat Prod Res. 2016 Jul;18(7):690-6. doi: 10.1080/10286020.2015.1134503. Epub 2016 Feb 1.

DOI:10.1080/10286020.2015.1134503

PMID:26828126

Abstract

A new compound, chandonanol (1), along with four known compounds, chandonanthone (2), iso-chandonanthone (3), anastreptene (4), and (6R,7S)-sesquiphellandrene (5), was isolated from the MeOH extract of Bornean liverwort Chandonanthus hirtellus. The structure of the new metabolite was established by analyses of the spectroscopic data (1D NMR, 2D NMR, HRESIMS, and IR). These compounds were tested for their activity against antibiotic-resistant clinical strains. Chandonanol (1) exhibited potent bactericidal activity against Staphylococcus aureus and Escherichia coli.

摘要

从婆罗洲地钱毛枝钱苔（Chandonanthus hirtellus）的甲醇提取物中分离出一种新化合物——钱苔醇（1），以及四种已知化合物——钱苔酮（2）、异钱苔酮（3）、阿那链菌素（4）和（6R,7S）-倍半水芹烯（5）。通过光谱数据（一维核磁共振、二维核磁共振、高分辨电喷雾电离质谱和红外光谱）分析确定了这种新代谢物的结构。测试了这些化合物对抗生素耐药临床菌株的活性。钱苔醇（1）对金黄色葡萄球菌和大肠杆菌表现出强效杀菌活性。