Centre for Child and Family Studies, Leiden University, The Netherlands.
Psychoneuroendocrinology. 2010 Nov;35(10):1454-61. doi: 10.1016/j.psyneuen.2010.04.012. Epub 2010 May 23.
Quality of the parent-infant attachment relationship influences physiological stress regulation. Genetic factors also contribute to the stress regulatory HPA-axis. Quality of attachment as an index of the rearing environment (measured with the Strange Situation Procedure, SSP), and HPA-axis related SNPs (BclI, rs41423247; TthIIII, rs10052957; GR-9β, rs6198; N363S, rs6195; ER22/23EK, rs6189 and 6190; and FKBP5, rs1360780) were hypothesized to be related to cortisol reactivity in the stressful SSP. In this large population based sample, FKBP5 rs1360780, but not GR haplotype, was related to cortisol reactivity. Moreover, we found a significant interaction effect for insecure-resistant attachment and FKBP5 rs1360780, indicating a double-risk for heightened cortisol reactivity levels in infants with one or two T-alleles of the FKBP5 SNP and an insecure-resistant attachment relationship with their mother. Findings are discussed from the perspective of gene-environment interaction.
母婴依恋关系的质量会影响生理应激调节。遗传因素也会影响 HPA 轴的应激调节。依恋质量作为养育环境的指标（通过陌生情境程序 SSP 测量），以及与 HPA 轴相关的 SNP（BclI，rs41423247；TthIIII，rs10052957；GR-9β，rs6198；N363S，rs6195；ER22/23EK，rs6189 和 6190；以及 FKBP5，rs1360780），被假设与应激性 SSP 中的皮质醇反应有关。在这个基于人群的大型样本中，FKBP5 rs1360780，但不是 GR 单倍型，与皮质醇反应有关。此外，我们发现不安全-抵抗依恋和 FKBP5 rs1360780 之间存在显著的交互作用效应，这表明在 FKBP5 SNP 的一个或两个 T 等位基因和与母亲的不安全-抵抗依恋关系的婴儿中，皮质醇反应水平升高的双重风险。研究结果从基因-环境相互作用的角度进行了讨论。
