HLA-DQ2+ 个体易患 Hu-Ab 相关副肿瘤性神经系统综合征。
HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes.
机构信息
Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
出版信息
J Neuroimmunol. 2010 Sep 14;226(1-2):147-9. doi: 10.1016/j.jneuroim.2010.05.035. Epub 2010 Jun 12.
BACKGROUND
Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS).
OBJECTIVE
To identify genetic risk factors for Hu-PNS and investigate the role of T cells.
METHODS
HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC).
RESULTS
The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in HC.
CONCLUSIONS
This study indicates an association between Hu-PNS and presence of HLA-DQ2 and HLA-DR3, which supports a role for CD4(+) T cells in the pathogenesis of Hu-PNS.
背景
据推测，T 细胞参与了与 Hu 抗体相关的副肿瘤性神经系统综合征（Hu-PNS）的发病机制。
目的
确定 Hu-PNS 的遗传风险因素，并探讨 T 细胞的作用。
方法
比较了 53 例 Hu-PNS 患者、24 例小细胞肺癌（SCLC）患者和 2440 例健康对照者的 HLA-A、B、DRB1 和 DQB1 等位基因。
结果
与健康对照组相比，Hu-PNS 患者 HLA-DQ2 和 HLA-DR3 的频率明显更高。
结论
本研究表明 Hu-PNS 与 HLA-DQ2 和 HLA-DR3 的存在之间存在关联，这支持了 CD4(+)T 细胞在 Hu-PNS 发病机制中的作用。
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