Tani Takashi, Tanaka Keiko, Idezuka Jiro, Nishizawa Masatoyo
Neurology, Brain Research Institute of Niigata University, Asahimachi Dori 1-757, Niigata-shi, Niigata, Japan.
J Neuroimmunol. 2008 May 30;196(1-2):166-9. doi: 10.1016/j.jneuroim.2008.03.002. Epub 2008 May 1.
Focusing on CD4(+)CD25(+) regulatory T lymphocytes (T(reg)), we studied the gene expression of T(reg) functional molecules in peripheral blood lymphocytes of patients with paraneoplastic neurological syndrome (PNS), including Lambert-Eaton myasthenic syndrome (LEMS) with small cell lung carcinoma (SCLC) and anti-Hu- or anti-Yo-antibody-positive PNS. T(reg)-rich subsets were sorted from the patients' peripheral blood mononuclear cells, and the mRNA expression levels of their functional genes were measured. The expression levels of FOXP3, TGF-beta and CTLA4 mRNA in T(reg)-rich subsets of PNS patients were down-regulated compared with that of SCLC patients without PNS. These results suggest that T(reg) dysfunction plays a role in PNS development.
聚焦于CD4(+)CD25(+)调节性T淋巴细胞（T(reg)），我们研究了副肿瘤性神经综合征（PNS）患者外周血淋巴细胞中T(reg)功能分子的基因表达，这些患者包括合并小细胞肺癌（SCLC）的兰伯特-伊顿肌无力综合征（LEMS）以及抗Hu或抗Yo抗体阳性的PNS患者。从患者外周血单个核细胞中分离出富含T(reg)的亚群，并测定其功能基因的mRNA表达水平。与无PNS的SCLC患者相比，PNS患者富含T(reg)亚群中FOXP3、TGF-β和CTLA4 mRNA的表达水平下调。这些结果表明T(reg)功能障碍在PNS的发生发展中起作用。
