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法国耐头孢他啶铜绿假单胞菌中产生的超广谱β-内酰胺酶、金属β-内酰胺酶和超广谱头孢菌素酶的全国性调查。

Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France.

机构信息

Centre National de Référence de la Résistance aux Antibiotiques, Laboratoire associé P. aeruginosa, Hôpital Jean Minjoz, Besançon, France.

出版信息

Antimicrob Agents Chemother. 2010 Aug;54(8):3512-5. doi: 10.1128/AAC.01646-09. Epub 2010 Jun 14.

Abstract

A nationwide study aimed to identify the extended-spectrum beta-lactamases (ESBLs), metallo-beta-lactamases (MBLs), and extended-spectrum oxacillinases (ES-OXAs) in a French collection of 140 clinical Pseudomonas aeruginosa isolates highly resistant to ceftazidime. Six ESBLs (PER-1, n=3; SHV-2a, n=2; VEB-1a, n=1), four MBLs (VIM-2, n=3; IMP-18, n=1), and five ES-OXAs (OXA-19, n=4; OXA-28, n=1) were identified in 13 isolates (9.3% of the collection). The prevalence of these enzymes is still low in French clinical P. aeruginosa isolates but deserves to be closely monitored.

摘要

一项全国性研究旨在鉴定法国收集的 140 株对头孢他啶高度耐药的临床铜绿假单胞菌分离株中的超广谱β-内酰胺酶(ESBLs)、金属β-内酰胺酶(MBLs)和超广谱头孢菌素酶(ES-OXAs)。在 13 株菌(占该菌集的 9.3%)中鉴定出 6 种 ESBLs(PER-1,n=3;SHV-2a,n=2;VEB-1a,n=1)、4 种 MBLs(VIM-2,n=3;IMP-18,n=1)和 5 种 ES-OXAs(OXA-19,n=4;OXA-28,n=1)。法国临床铜绿假单胞菌分离株中这些酶的流行率仍然较低,但值得密切监测。

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