Centre National de Référence de la Résistance aux Antibiotiques, Laboratoire associé P. aeruginosa, Hôpital Jean Minjoz, Besançon, France.
Antimicrob Agents Chemother. 2010 Aug;54(8):3512-5. doi: 10.1128/AAC.01646-09. Epub 2010 Jun 14.
A nationwide study aimed to identify the extended-spectrum beta-lactamases (ESBLs), metallo-beta-lactamases (MBLs), and extended-spectrum oxacillinases (ES-OXAs) in a French collection of 140 clinical Pseudomonas aeruginosa isolates highly resistant to ceftazidime. Six ESBLs (PER-1, n=3; SHV-2a, n=2; VEB-1a, n=1), four MBLs (VIM-2, n=3; IMP-18, n=1), and five ES-OXAs (OXA-19, n=4; OXA-28, n=1) were identified in 13 isolates (9.3% of the collection). The prevalence of these enzymes is still low in French clinical P. aeruginosa isolates but deserves to be closely monitored.
一项全国性研究旨在鉴定法国收集的 140 株对头孢他啶高度耐药的临床铜绿假单胞菌分离株中的超广谱β-内酰胺酶(ESBLs)、金属β-内酰胺酶(MBLs)和超广谱头孢菌素酶(ES-OXAs)。在 13 株菌(占该菌集的 9.3%)中鉴定出 6 种 ESBLs(PER-1,n=3;SHV-2a,n=2;VEB-1a,n=1)、4 种 MBLs(VIM-2,n=3;IMP-18,n=1)和 5 种 ES-OXAs(OXA-19,n=4;OXA-28,n=1)。法国临床铜绿假单胞菌分离株中这些酶的流行率仍然较低,但值得密切监测。