控制小鼠α-半乳糖苷酶表达的X连锁基因和常染色体基因。
X-linked and autosomal genes controlling mouse alpha-galactosidase expression.
作者信息
Lusis A J, West J D
出版信息
Genetics. 1978 Feb;88(2):327-42. doi: 10.1093/genetics/88.2.327.
Abstract
Analysis of F2 and backcross animals has confirmed the X-chromosome linkage of Ags, the structural locus for mouse alpha-galactosidase. The position of Ags has been located in the X chromosome, 9 centimorgans from Mo, and the gene order is centromere-Hq-Bn-Ta-Mo-Ags. A variation in the developmental expression of alpha-galactosidase activity, inherited as an autosomal trait, has been characterized using recombinant inbred lines of mice. Among certain recombinant inbred lines, the variation appears to segregate as a single major locus.
摘要
对F2代和回交动物的分析证实了Ags（小鼠α-半乳糖苷酶的结构基因座）与X染色体连锁。Ags的位置已定位在X染色体上，距离Mo基因9厘摩，基因顺序为着丝粒-Hq-Bn-Ta-Mo-Ags。利用小鼠重组近交系，对作为常染色体性状遗传的α-半乳糖苷酶活性发育表达的变异进行了表征。在某些重组近交系中，这种变异似乎作为一个单一的主要基因座进行分离。
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