野生来源小鼠中X染色体连锁的次黄嘌呤磷酸核糖基转移酶（HPRT）的电泳变异
Electrophoretic variation for X chromosome-linked hypoxanthine phosphoribosyl transferase (HPRT) in wild-derived mice.
作者信息
Chapman V M, Kratzer P G, Quarantillo B A
出版信息
Genetics. 1983 Apr;103(4):785-95. doi: 10.1093/genetics/103.4.785.
Abstract
An electrophoretic variation for hypoxanthine phosphoribosyltransferase, HPRT, has been identified in samples of Mus spretus, a field mouse from southern Europe and in M. m. castaneus, a house mouse from southeast Asia. These mice will interbreed with laboratory mice to produce viable, fertile F1 progeny. The variation for HPRT segregates as an X chromosome gene in F1 and backcross progeny. Linkage analysis involving the markers Pgk-1 and Ags indicated a gene order of centromere--Hprt--Pgk-1--Ags in crosses involving both stocks of wild mice.
摘要
在来自南欧的野生小家鼠（Mus spretus）和来自东南亚的家鼠（M. m. castaneus）样本中，已鉴定出次黄嘌呤磷酸核糖转移酶（HPRT）的一种电泳变异。这些小鼠能与实验室小鼠杂交产生可存活、可育的F1代后代。HPRT变异在F1代和回交后代中作为X染色体基因进行分离。在涉及两种野生小鼠品系的杂交中，利用磷酸甘油酸激酶-1（Pgk-1）和精氨酸酶（Ags）标记进行的连锁分析表明基因顺序为着丝粒-Hprt-Pgk-1-Ags。
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