西洋参中的细胞毒性乙炔类化合物。
Cytotoxic acetylenes from Panax quinquefolium.
作者信息
Fujimoto Y, Satoh M, Takeuchi N, Kirisawa M
机构信息
College of Pharmacy, Nihon University, Chiba, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1991 Feb;39(2):521-3. doi: 10.1248/cpb.39.521.
PMID:2054881
Abstract
Three new cytotoxic polyacetylenes, PQ-1 (1), PQ-2 (2) and PQ-3 (3), have been isolated from Panax quinquefolium. The structures of these acetylenes were determined by analyses of their 1H-1H and 1H-13C COSY spectra. All these compounds exhibited strong cytotoxic activities against leukemia cells (L 1210) in tissue culture.
摘要
从西洋参中分离出了三种新的具有细胞毒性的聚乙炔化合物，即PQ-1（1）、PQ-2（2）和PQ-3（3）。通过对它们的1H-1H和1H-13C化学位移相关谱的分析确定了这些乙炔化合物的结构。所有这些化合物在组织培养中均对白血病细胞（L 1210）表现出强烈的细胞毒性活性。
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