一种来自树参的细胞毒性二乙炔。
A cytotoxic diacetylene from Dendropanax arboreus.
作者信息
Setzer W N, Green T J, Whitaker K W, Moriarity D M, Yancey C A, Lawton R O, Bates R B
出版信息
Planta Med. 1995 Oct;61(5):470-1. doi: 10.1055/s-2006-958139.
PMID:7480210
Abstract
The crude ethanol extract from the leaves of Dendropanax arboreus (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, H-4IIE, and L-1210 tumor cell lines, but is not toxic against normal hepatocytes. The active component has been isolated by activity-directed separation and identified by 1H- and 13C-NMR spectroscopy as the acetylenic compound cis-1,9,16-heptadecatriene-4,6-diyne-3,8-diol.
摘要
来自哥斯达黎加蒙特维德的树参（五加科）叶片的粗乙醇提取物对Hep-G2、A-431、H-4IIE和L-1210肿瘤细胞系具有细胞毒性活性，但对正常肝细胞无毒。活性成分已通过活性导向分离法分离，并通过1H-和13C-核磁共振光谱鉴定为炔类化合物顺式-1,9,16-十七碳三烯-4,6-二炔-3,8-二醇。
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