Genetics and Molecular Biology Unit - Medical School - São José do Rio Preto - FAMERP.
Braz J Otorhinolaryngol. 2010 Mar-Apr;76(2):193-8. doi: 10.1590/S1808-86942010000200008.
In Brazil, there were 14,160 new estimated cases of head and neck cancer for the year of 2008. Smoking and drinking are the main risk factors established in the etiology of this disease.
To assess the T --> A polymorphism in gene TAX1BP1 (leu306ile) in patients with head and neck cancer and a control population. SERIES AND METHODS: A retrospective study in which we assessed the gender, age, smoking and drinking habits of 191 patients with head and neck cancer and 200 individuals without history of neoplasia. The molecular analysis was carried out after genomic DNA extraction by the PCR-RFLP method.
There is a predominance of males (84.82%), smokers (91.1%) and drinkers of alcohol (77.49%). Molecular assessment did not show statistically significant differences between the two groups (p =0.32). The analysis of clinical parameters and polymorphisms showed association with oral cavity cancer (OR: 2.38; CI 95%: 1.18-4.78; p = 0.01), the other parameters were not associated with the polymorphism.
There is evidence of association between TAX1BP1 gene polymorphism and oral cavity cancer. For the remaining parameters analyzed, the results do not suggest association with the TAX1BP1 gene polymorphism.
2008 年，巴西有 14160 例新的头颈部癌症估计病例。吸烟和饮酒是该疾病病因学中确立的主要危险因素。
评估头颈部癌症患者和对照组人群中 TAX1BP1 基因（leu306ile）的 T --> A 多态性。
这是一项回顾性研究，我们评估了 191 例头颈部癌症患者和 200 例无肿瘤病史个体的性别、年龄、吸烟和饮酒习惯。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法提取基因组 DNA 后进行分子分析。
男性（84.82%）、吸烟者（91.1%）和饮酒者（77.49%）居多。两组间的分子评估无统计学差异（p =0.32）。临床参数和多态性分析显示与口腔癌有关（OR：2.38；95%CI：1.18-4.78；p = 0.01），其他参数与多态性无关。
TAX1BP1 基因多态性与口腔癌之间存在关联的证据。对于分析的其余参数，结果不提示与 TAX1BP1 基因多态性有关。
