Australian Academy of Sciences, West Pennant Hills, NSW, Australia.
Biogerontology. 2010 Aug;11(4):507-11. doi: 10.1007/s10522-010-9288-1. Epub 2010 Jun 15.
The biological reasons for ageing are now well known, so it is no longer an unsolved problem in biology. Furthermore, there is only one science of ageing, which is continually advancing. The significance and importance of the mutations that lengthen the lifespan of invertebrates can be assessed only in relationship to previous well-established studies of ageing. The mutant strains of model organisms that increase longevity have altered nutrient signalling pathways similar to the effects of dietary restriction, and so it is likely that there is a shift in the trade-off between reproduction and maintenance of the soma. To believe that the isolation and characterisation of a few invertebrate mutations (as well as those in yeast) will "galvanise" the field and provide new insights into human ageing is an extreme point of view which does not recognize the huge progress in ageing research that has been made in the last 50 years or so.
衰老的生物学原因现在已经众所周知，因此它不再是生物学中的一个未解难题。此外，只有一门衰老学在不断发展。只有将延长无脊椎动物寿命的突变的意义和重要性与之前关于衰老的既定研究联系起来进行评估，才能对其进行评估。延长寿命的模式生物的突变株改变了营养信号通路，类似于饮食限制的影响，因此很可能在繁殖和体细胞维护之间的权衡上发生了转变。认为分离和鉴定少数几种无脊椎动物突变（以及酵母中的突变）将“激发”该领域，并为人类衰老提供新的见解，这种观点是极端的，它没有认识到过去 50 年来衰老研究已经取得了巨大进展。
