Department of Molecular Biology and Genetics, Aarhus University, 8000, Aarhus C, Denmark.
Biogerontology. 2024 Feb;25(1):1-8. doi: 10.1007/s10522-023-10089-0.
About a year ago, members of the editorial board of Biogerontology were requested to respond to a query by the editor-in-chief of the journal as to what one question within their field of ageing research still needs to be asked and answered. This editorial is inspired by the wide range and variety of questions, ideas, comments and suggestions received in response to that query. The seven knowledge gaps identified in this article are arranged into three main categories: evolutionary aspects of longevity, biological survival and death aspects, and heterogeneity in the progression and phenotype of ageing. This is not an exhaustive and exclusive list, and may be modified and expanded. Implications of these knowledge gaps, especially in the context of ongoing attempts to develop effective interventions in ageing and longevity are also discussed.
大约一年前，《生物老年学》杂志的编辑委员会成员被要求对主编提出的一个问题作出回应，这个问题是在他们的衰老研究领域内，还有哪一个问题需要被提出并回答。这篇社论的灵感来自于对该问题的广泛的回应，这些回应包括各种问题、想法、评论和建议。本文确定的七个知识空白被分为三个主要类别：长寿的进化方面、生物生存和死亡方面以及衰老进程和表型的异质性。这不是一个详尽和排他的列表，可能会被修改和扩展。还讨论了这些知识空白的影响，特别是在当前试图开发衰老和长寿干预措施的背景下。
