Department of Pathology and Diagnostics, Division of General Pathology, University of Verona, Verona, Italy.
Eur J Immunol. 2010 Sep;40(9):2360-8. doi: 10.1002/eji.200940294.
Analysis of the molecular mechanisms governing the ability of IL-10 to keep inflammation under control has highlighted the existence of a great degree of plasticity and specificity with regard to innate immune cells. In this respect, neutrophils represent a perfect example of innate immune cells conditioned by external signals (for instance, by LPS), as well as by intracellular regulatory pathways, that render them optimally responsive to IL-10 only when required. The focus of this review are the recent experimental findings that have uncovered the sophisticated and complex molecular mechanisms responsible for the modulation of pro- and anti-inflammatory cytokine production by IL-10 in neutrophils and other innate immune cells. Understanding how IL-10 exerts its anti-inflammatory response, particularly in the case of neutrophils, will provide novel clues leading, hopefully, to the therapeutic control of neutrophil-driven inflammatory reactions, such as septic infections, rheumatoid arthritis, osteoarthritis and chronic obstructive pulmonary disease.
分析调控白细胞介素 10（IL-10）炎症能力的分子机制，突出了先天免疫细胞具有高度可塑性和特异性。在这方面，中性粒细胞是先天免疫细胞的一个完美范例，受外部信号（例如 LPS）以及细胞内调节途径的调节，使其在需要时对 IL-10 做出最佳反应。本综述的重点是最近的实验发现，这些发现揭示了复杂而精细的分子机制，负责调节中性粒细胞和其他先天免疫细胞中促炎和抗炎细胞因子的产生。了解 IL-10 如何发挥抗炎作用，特别是在中性粒细胞中，将为治疗控制中性粒细胞驱动的炎症反应（如败血症感染、类风湿关节炎、骨关节炎和慢性阻塞性肺疾病）提供新的线索。
