Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Cientificas, and Universidad Miguel Hernández, Sant Joan d'Alacant, Spain.
Dev Dyn. 2010 Jul;239(7):2094-101. doi: 10.1002/dvdy.22327.
The components of the molecular codes needed to specify the different neuronal populations present in the basal neural tube are being identified. These codes become more intricate as we move to more anterior regions of the central nervous system. The aim of this study is to thoroughly analyze the expression pattern of Nkx6.1, Nkx6.2, and Pou4f1. These three genes are candidates to play an important role in the determination and differentiation of the basal nuclei of the mesencephalon and diencephalon. The results obtained have shown that there is a longitudinal domain positive for both Nkx6.1 and Nkx6.2 that is medial to the Pou4f1-positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon. The nuclei integrated in this domain would be the rostral interstitial nucleus, the interstitial nucleus of Cajal, and a mesencephalic equivalent to these nuclei.
目前正在鉴定指定基板神经管中存在的不同神经元群体所需的分子代码的组成部分。随着我们向中枢神经系统的更前区域移动，这些代码变得更加复杂。本研究的目的是彻底分析 Nkx6.1、Nkx6.2 和 Pou4f1 的表达模式。这三个基因是在确定和分化中脑和间脑的基底核中发挥重要作用的候选基因。获得的结果表明，存在一个对 Nkx6.1 和 Nkx6.2 均呈阳性的纵向区域，该区域位于 Pou4f1 阳性的红核的内侧。该区域可能对应于从间脑和中脑延伸的网状结构的一部分。整合在该区域中的核将是前间核、Cajal 间质核以及这些核的中脑等效核。
