一种铑 IBiox[(-)-薄荷基]配合物作为高对映选择性催化剂用于氮杂环丁烷的不对称氢芳基化：一种制备埃巴他啶的替代途径。
A rhodium IBiox[(-)-menthyl] complex as a highly selective catalyst for the asymmetric hydroarylation of azabicyles: an alternative route to epibatidine.
机构信息
Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3H6.
出版信息
Org Lett. 2010 Jul 16;12(14):3160-3. doi: 10.1021/ol101067d.
PMID:20550216
Abstract
The synthesis and characterization of a new chiral rhodium N-heterocyclic carbene complex, Rh(IBiox(-)-menthyl(2)Cl, is reported. In addition, the very high enantioselectivity exhibited by this complex, as a catalyst for the asymmetric hydroarylation of azabicycles, is demonstrated and applied to the synthesis of epibatidine.
摘要
报告了一种新型手性铑 N-杂环卡宾配合物 Rh(IBiox(-)-menthyl(2)Cl 的合成与表征。此外，还证明了该配合物作为催化剂在氮杂环化合物的不对称氢芳基化反应中表现出的极高对映选择性，并将其应用于埃派他丁的合成。
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