Feizabadi Mitra S, Witten Tarynn M
Physics Department, Seton Hall University, South Orange, NJ 07079, USA.
Theor Biol Med Model. 2010 Jun 15;7:21. doi: 10.1186/1742-4682-7-21.
In this paper we consider two approaches to examining the complex dynamics of conjoint aging-cancer cellular systems undergoing chemotherapeutic intervention. In particular, we focus on the effect of cells growing conjointly in a culture plate as a precursor to considering the larger multi-dimensional models of such systems. Tumor cell growth is considered from both the logistic and the Gompertzian case, while normal cell growth of fibroblasts (WI-38 human diploid fibroblasts) is considered as logistic only.
We demonstrate, in a simple approach, how the interdependency of different cell types in a tumor, together with specifications of for treatment, can lead to different evolutionary patterns for normal and tumor cells during a course of therapy.
These results have significance for understanding appropriate pharmacotherapy for elderly patients who are also undergoing chemotherapy.
在本文中，我们考虑了两种方法来研究接受化疗干预的衰老与癌症联合细胞系统的复杂动力学。特别地，我们将重点关注在培养皿中共同生长的细胞的影响，以此作为考虑此类系统更大的多维模型的前奏。肿瘤细胞生长从逻辑斯谛模型和冈珀茨模型两种情况进行考虑，而成纤维细胞（WI - 38人二倍体成纤维细胞）的正常细胞生长仅从逻辑斯谛模型考虑。
我们以一种简单的方法证明了肿瘤中不同细胞类型的相互依赖性以及治疗规范如何在治疗过程中导致正常细胞和肿瘤细胞出现不同的进化模式。
这些结果对于理解正在接受化疗的老年患者的适当药物治疗具有重要意义。
