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T 型增长模型及其在肿瘤免疫动力学系统中的应用。

T model of growth and its application in systems of tumor-immune dynamics.

机构信息

Department of Mathematical Sciences, Cameron University, Lawton, OK 73505, USA.

出版信息

Math Biosci Eng. 2013 Jun;10(3):925-38. doi: 10.3934/mbe.2013.10.925.

Abstract

In this paper we introduce a new growth model called T growth model. This model is capable of representing sigmoidal growth as well as biphasic growth. This dual capability is achieved without introducing additional parameters. The T model is useful in modeling cellular proliferation or regression of cancer cells, stem cells, bacterial growth and drug dose-response relationships. We recommend usage of the T growth model for the growth of tumors as part of any system of differential equations. Use of this model within a system will allow more flexibility in representing the natural rate of tumor growth. For illustration, we examine some systems of tumor-immune interaction in which the T growth rate is applied. We also apply the model to a set of tumor growth data.

摘要

在本文中,我们介绍了一种新的增长模型,称为 T 增长模型。该模型能够表示 S 型增长和双相增长。这种双重能力是在不引入额外参数的情况下实现的。T 模型在建模癌细胞、干细胞、细菌生长和药物剂量反应关系的细胞增殖或衰退方面非常有用。我们建议在微分方程系统中使用 T 增长模型来描述肿瘤的生长。在系统中使用该模型可以更灵活地表示肿瘤的自然生长速度。为了说明这一点,我们研究了一些肿瘤-免疫相互作用的系统,其中应用了 T 增长率。我们还将该模型应用于一组肿瘤生长数据。

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本文引用的文献

1
Myeloid cells in tumour-immune interactions.肿瘤免疫相互作用中的髓系细胞。
J Biol Dyn. 2010 Jul;4(4):315-27. doi: 10.1080/17513750903261281.
5
Mathematical modeling of stem cell proliferation.干细胞增殖的数学建模。
Med Biol Eng Comput. 2011 Mar;49(3):253-62. doi: 10.1007/s11517-010-0686-y. Epub 2010 Oct 16.
8
On optimal delivery of combination therapy for tumors.关于肿瘤联合治疗的最优化输送。
Math Biosci. 2009 Nov;222(1):13-26. doi: 10.1016/j.mbs.2009.08.004. Epub 2009 Aug 23.
10
Modeling of cancer virotherapy with recombinant measles viruses.重组麻疹病毒用于癌症病毒疗法的建模
J Theor Biol. 2008 May 7;252(1):109-22. doi: 10.1016/j.jtbi.2008.01.016. Epub 2008 Feb 1.

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