Department of Rheumatology, Hospital Juárez de México, México DF, México.
Int J Tuberc Lung Dis. 2010 Jul;14(7):916-20.
Tuberculous rheumatism (Poncet's disease) is a reactive polyarthropathy associated with extra-pulmonary and pulmonary tuberculosis (TB) without evidence of mycobacterial infection of the involved joints. As all patients with TB do not present with this peculiar clinical feature, a genetic susceptibility is suspected.
To determine the major histocompatibility complex (MHC) class I and II alleles in Mexican mestizo patients with Poncet's disease.
In this case-control study of 16 Mexican mestizo patients diagnosed with Poncet's disease and 99 ethnically matched healthy controls, high resolution human leukocyte antigen (HLA) typing was performed for HLA-A, B, DR and DQ by polymerase chain reaction. HLA-DRB1 and HLA-DQB1 subtypes were performed by sequence-specific oligonucleotide probe hybridization.
A significantly increased frequency of HLA-B27 (corrected P = 0.01) and DQB10301 (corrected P = 0.0009) alleles and decreased frequency of HLA-DQB10302 (corrected P = 0.00001) were identified in patients compared to healthy controls.
These data suggest that genes located within the MHC may play a role in the susceptibility to Poncet's disease in patients diagnosed with TB.
结核性风湿病（庞赛氏病）是一种与肺外和肺结核（TB）相关的反应性多关节炎，没有受累关节分枝杆菌感染的证据。由于并非所有 TB 患者都具有这种特殊的临床特征，因此怀疑存在遗传易感性。
确定墨西哥混血儿患者中庞赛氏病的主要组织相容性复合体（MHC）I 类和 II 类等位基因。
在这项对 16 名被诊断患有庞赛氏病的墨西哥混血儿患者和 99 名具有匹配种族的健康对照者的病例对照研究中，通过聚合酶链反应对人类白细胞抗原（HLA）-A、B、DR 和 DQ 进行高分辨率 HLA 分型，通过序列特异性寡核苷酸探针杂交进行 HLA-DRB1 和 HLA-DQB1 亚型分析。
与健康对照组相比，患者中 HLA-B27（校正 P = 0.01）和 DQB10301（校正 P = 0.0009）等位基因的频率显著增加，而 HLA-DQB10302（校正 P = 0.00001）的频率降低。
这些数据表明，位于 MHC 内的基因可能在诊断为 TB 的患者中易患庞赛氏病方面发挥作用。
