Neuroscience, University of Kansas, 1000 Sunnyside Avenue, Lawrence, KS 66045, USA.
Brain Res. 2010 Aug 12;1348:63-70. doi: 10.1016/j.brainres.2010.06.015. Epub 2010 Jun 13.
A new pneumatic tactile stimulator, called the TAC-Cell, was developed in our laboratory to non-invasively deliver patterned cutaneous stimulation to the face and hand in order to study the neuromagnetic response adaptation patterns within the primary somatosensory cortex (S1) in young adult humans. Individual TAC-Cells were positioned on the glabrous surface of the right hand, and midline of the upper and lower lip vermilion. A 151-channel magnetoencephalography (MEG) scanner was used to record the cortical response to a novel tactile stimulus which consisted of a repeating 6-pulse train delivered at three different frequencies through the active membrane surface of the TAC-Cell. The evoked activity in S1 (contralateral for hand stimulation, and bilateral for lip stimulation) was characterized from the best-fit dipoles of the earliest prominent response component. The S1 responses manifested significant modulation and adaptation as a function of the frequency of the punctate pneumatic stimulus trains and stimulus site (glabrous lip versus glabrous hand).
我们实验室开发了一种新型气动触觉刺激器，称为 TAC-Cell，用于对面部和手部进行非侵入式的模式化皮肤刺激，以研究年轻成年人类初级体感皮层 (S1) 中的神经磁响应适应模式。单个 TAC-Cell 被放置在右手的无毛发表面以及上唇和下唇唇红的中线。使用 151 通道脑磁图 (MEG) 扫描仪记录皮质对新型触觉刺激的反应，该刺激由通过 TAC-Cell 的主动膜表面以三种不同频率传递的重复 6 脉冲序列组成。S1 中的诱发活动（对手部刺激为对侧，对唇部刺激为双侧）是从最早突出响应分量的最佳拟合偶极子来表征的。S1 响应表现出显著的调制和适应，这是作为点状气动刺激序列的频率和刺激部位（无毛发的嘴唇与无毛发的手）的函数。
