Royal Brisbane and Women's Hospital, University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia.
Nutr Metab (Lond). 2010 Jun 16;7:50. doi: 10.1186/1743-7075-7-50.
To determine whether liver fat percent (LFP) is associated with the metabolic syndrome independently of visceral fat area (VFA).
43 High-risk vascular patients not on lipid-lowering therapy were evaluated for the Adult Treatment Panel III (ATPIII) metabolic syndrome criteria and underwent magnetic resonance imaging (MRI) to quantify VFA and subcutaneous fat area (SFA) at the L4-L5 disc and liver magnetic resonance spectroscopy (MRS) to quantify LFP. Comparisons: 1. Baseline differences in patients with and without the metabolic syndrome 2. Forward binary logistic regression analysis of predictors of the metabolic syndrome with VFA, SFA and LFP as independents 3. Correlates of LFP.
43 patients were included in analysis. Patients with metabolic syndrome had greater VFA, SFA and LFP than patients without the metabolic syndrome (all p < 0.01). Of VFA, SFA and LFP, only LFP was associated with the diagnosis of the metabolic syndrome on forward binary logistic regression with an OR of 1.17 per 1% increase in LFP (p = 0.015). A 4% LFP threshold identified the metabolic syndrome with 84% sensitivity and 82% specificity. LFP correlated with waist circumference (r = 0.768), HDL-cholesterol (r = -0.342), triglyceride (r = 0.369), fasting glucose (r = 0.584) and the QUICK Index of insulin sensitivity (r = -0.679) (all p < 0.05)
LFP is associated with the metabolic syndrome and renders the current gold standard of VFA redundant in this analysis. This measure of obesity-related cardiovascular risk requires further validation and evaluation in a prospective cohort.
确定肝脂肪百分比（LFP）是否与代谢综合征独立于内脏脂肪面积（VFA）相关。
43 名未接受降脂治疗的高危血管患者接受了成人治疗小组 III（ATPIII）代谢综合征标准评估，并进行了磁共振成像（MRI）以量化 L4-L5 椎间盘处的 VFA 和皮下脂肪面积（SFA），以及肝脏磁共振波谱（MRS）以量化 LFP。比较：1. 代谢综合征患者与无代谢综合征患者的基线差异；2. VFA、SFA 和 LFP 作为独立因素对代谢综合征的正向二项逻辑回归分析；3. LFP 的相关性。
43 名患者纳入分析。代谢综合征患者的 VFA、SFA 和 LFP 均大于无代谢综合征患者（均 p < 0.01）。在 VFA、SFA 和 LFP 中，只有 LFP 与代谢综合征的诊断相关，LFP 每增加 1%，OR 为 1.17（p = 0.015）。4%的 LFP 阈值可识别代谢综合征，其灵敏度为 84%，特异性为 82%。LFP 与腰围（r = 0.768）、HDL-胆固醇（r = -0.342）、甘油三酯（r = 0.369）、空腹血糖（r = 0.584）和 QUICK 胰岛素敏感性指数（r = -0.679）相关（均 p < 0.05）。
LFP 与代谢综合征相关，在本分析中使当前的 VFA 金标准变得多余。这种肥胖相关心血管风险的衡量标准需要在前瞻性队列中进一步验证和评估。
