Coenraad S, Goedegebure A, van Goudoever J B, Hoeve L J
Department of Otorhinolaryngology, Sophia Children's Hospital-Erasmus Medical Center, Rotterdam, Netherlands.
Int J Pediatr Otorhinolaryngol. 2010 Sep;74(9):999-1002. doi: 10.1016/j.ijporl.2010.05.024. Epub 2010 Jun 15.
To evaluate independent etiologic factors associated with sensorineural hearing loss in infants who have been admitted to the neonatal intensive care unit compared to normal hearing controls.
Between 2004 and 2009, 3366 infants were admitted to the neonatal intensive care unit of Sophia Children's Hospital, of which 3316 were screened with AABR. A total of 103 infants were referred for auditory brainstem response analysis after failure on neonatal hearing screening. We included all infants diagnosed with sensorineural hearing loss. Each patient was matched with two normal hearing controls from the neonatal intensive care unit of the same gender and postconceptional age. The following risk factors were studied: birth weight, dysmorphic features, APGAR scores (at 1, 5 and 10 min), respiratory distress (IRDS), CMV infection, sepsis, meningitis, cerebral bleeding, cerebral infarction, hyperbilirubinemia requiring phototherapy, peak total bilirubin level, furosemide, dexamethason, vancomycin, gentamycin and tobramycin administration.
Fifty-eight infants were diagnosed with sensorineural hearing loss: 26 girls and 32 boys. The incidence of dysmorphic features (P=0.000), low APGAR score (1 min) (P=0.01), sepsis (P=0.003), meningitis (P=0.013), cerebral bleeding (P=0.016) and cerebral infarction (P=0.000) were significantly increased in infants with sensorineural hearing loss compared to normal hearing controls (n=116).
Dysmorphic features, low APGAR scores at 1 min, sepsis, meningitis, cerebral bleeding and cerebral infarction are associated with sensorineural hearing loss independent of neonatal intensive care unit admittance.
评估入住新生儿重症监护病房的婴儿与听力正常的对照组相比，感音神经性听力损失的独立病因学因素。
2004年至2009年期间，3366名婴儿入住索菲亚儿童医院新生儿重症监护病房，其中3316名接受了自动听性脑干反应（AABR）筛查。共有103名婴儿在新生儿听力筛查未通过后被转诊进行听性脑干反应分析。我们纳入了所有被诊断为感音神经性听力损失的婴儿。每位患者与两名来自同一性别和孕龄的新生儿重症监护病房听力正常的对照组进行匹配。研究了以下危险因素：出生体重、畸形特征、阿氏评分（1、5和10分钟时）、呼吸窘迫（IRDS）、巨细胞病毒感染、败血症、脑膜炎、脑出血、脑梗死、需要光疗的高胆红素血症、总胆红素峰值水平、呋塞米、地塞米松、万古霉素、庆大霉素和妥布霉素的使用情况。
58名婴儿被诊断为感音神经性听力损失：26名女孩和32名男孩。与听力正常的对照组（n = 116）相比，感音神经性听力损失婴儿的畸形特征发生率（P = 0.000）、低阿氏评分（1分钟时）（P = 0.01）、败血症（P = 0.003）、脑膜炎（P = 0.013）、脑出血（P = 0.016）和脑梗死（P = 0.000）显著增加。
畸形特征、1分钟时的低阿氏评分、败血症、脑膜炎、脑出血和脑梗死与感音神经性听力损失相关，与入住新生儿重症监护病房无关。
