Equine Infectious Disease Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Texas A&M University, College Station, TX 77845, USA.
Vet Microbiol. 2010 Nov 20;146(1-2):175-8. doi: 10.1016/j.vetmic.2010.05.027. Epub 2010 May 27.
The objective of this study was to determine the in vitro antimicrobial activity of gallium maltolate (GaM) against Rhodococcus equi. A total of 98 virulent bacterial isolates from equine clinical cases were examined, of which 19 isolates were known to be resistant to macrolides and rifampin. Isolates were cultured with various concentrations of GaM and minimal inhibitory concentration (MIC) values were determined after 24 and 48 h. Both the MIC(50) and the MIC(90) after 24h of growth were 558 ng/mL (8 μM) and after 48 h of growth were 2230 ng/mL (32 μM). There were no apparent differences between MICs of macrolide-resistant and macrolide-susceptible isolates.
本研究旨在测定马酸镓（GaM）对马红球菌的体外抗菌活性。共检测了 98 株来自马临床病例的毒力分离株，其中 19 株已知对大环内酯类和利福平耐药。分离株用不同浓度的 GaM 培养，24 和 48 h 后测定最小抑菌浓度（MIC）值。24 h 生长后的 MIC(50)和 MIC(90)分别为 558 ng/mL（8 μM）和 48 h 生长后的 MIC(50)和 MIC(90)分别为 2230 ng/mL（32 μM）。大环内酯类耐药和敏感分离株的 MIC 无明显差异。
