Caffarra P, Scaglioni A, Malvezzi L, Girotti F, Soliveri P, Musicco M, Previdi P
Department of Neurology, University of Parama, Italy.
Funct Neurol. 1991 Jan-Mar;6(1):23-7.
The Fuld formula and the linear discriminant function applied to WAIS subtest scores were tested for their ability to identify Alzheimer's disease and senile dementia of the Alzheimer type in a group of 101 demented subjects. The sensitivity and specificity of Fuld's formula for Alzheimer dementia against other dementias were 44.2% and 73.8% respectively; when compared with an age-matched normal control group specificity was 91.4%. When the linear discriminant function was applied only WAIS subtest scores in "similarities and digit span" and "object assembly" significantly differentiated Alzheimer from other dementias (sensitivity 61.5% and specificity 63.3%). Specificity increased to 97.1% when the function was applied to discriminate Alzheimer from normal controls. Discriminant analysis applied to other WAIS subtests for the two demented groups revealed "picture completion" as significantly differentiating the groups but it did not contribute to diagnostic accuracy. WAIS scores are of limited value in the differential diagnosis of dementias.
在一组101名痴呆患者中，对应用于韦氏成人智力量表（WAIS）子测验分数的富尔德公式和线性判别函数识别阿尔茨海默病及阿尔茨海默型老年痴呆的能力进行了测试。富尔德公式针对阿尔茨海默痴呆与其他痴呆的敏感性和特异性分别为44.2%和73.8%；与年龄匹配的正常对照组相比，特异性为91.4%。应用线性判别函数时，仅WAIS子测验中的“相似性和数字广度”及“图形拼凑”分数能显著区分阿尔茨海默病与其他痴呆（敏感性61.5%，特异性63.3%）。当该函数用于区分阿尔茨海默病与正常对照组时，特异性增至97.1%。对两个痴呆组的其他WAIS子测验进行判别分析显示，“图片填充”能显著区分两组，但对诊断准确性并无贡献。WAIS分数在痴呆的鉴别诊断中价值有限。
