Feery B J
Med J Aust. 1977 Aug 6;2(6):180-3. doi: 10.5694/j.1326-5377.1977.tb114544.x.
Nine hundred and thirty-eight reports of adverse reactions of smallpox vaccination in Australia between 1960 and 1976 have been analysed according to the type of reaction, and the age and sex of vaccinee. In an estimated 5,000,000 vaccinations, the reaction rate was 188/million, and the death rate 1-5/million. Generalized vaccinia was the most common reaction. The more serious reactions--eczema vaccinatum, progressive vaccinia, and neurological and cardiac complications--accounted for 7-4% of the reports. A small number of rarely reported non-specific inflammatory reactions is also included. There was a marked difference in the number of reactions reported in females and males (the female-male ratio was 1-6:1), and this difference increased with age. Paradoxically, of eight reports of cardiac complications, seven concerned males. The administration of vaccinial immune globulin was usually followed by a rapid resolution of the adverse reactions.
对1960年至1976年间澳大利亚938例天花疫苗接种不良反应报告，按照反应类型、受种者年龄和性别进行了分析。在估计500万次接种中，反应率为188/百万，死亡率为1.5/百万。全身性牛痘是最常见的反应。较严重的反应——牛痘性湿疹、进行性牛痘以及神经和心脏并发症——占报告的7.4%。还包括少数报告较少的非特异性炎症反应。女性和男性报告的反应数量存在显著差异（女性与男性比例为1.6:1），且这种差异随年龄增加而增大。矛盾的是，在8例心脏并发症报告中，有7例涉及男性。接种牛痘免疫球蛋白后，不良反应通常迅速消退。
