Centre for Blistering Diseases, Department of Dermatology, University Medical Centre Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, the Netherlands.
Eur J Dermatol. 2010 Jul-Aug;20(4):451-6. doi: 10.1684/ejd.2010.1007. Epub 2010 Jun 17.
Staphylococcal scalded skin syndrome (SSSS) is a blistering disease of the skin caused by an infection with certain strains of Staphylococcus aureus. In vitro studies have suggested that exfoliative toxins secreted by these bacteria cleave the desmosomal adhesion molecule desmoglein 1 leading to loss of cell-cell contact in the superficial epidermis. In this study we investigated the fate of desmoglein 1 in biopsies of patients with SSSS to see whether the ectodomain of desmoglein 1 is cleaved. Our data largely confirm previous in vitro data. The different biopsies demonstrated the loss of the ectodomain of desmoglein 1 to different degrees. The endodomain of desmoglein 1 meanwhile remained present. Most remarkably, in one of our patients, the immunofluorescent analysis demonstrated that not desmoglein1 but desmocollin 1, another desmosomal cadherin, became affected. This raises the question if other toxins and/or other bacteria than Staphylococcus aureus might also induce SSSS.
葡萄球菌性烫伤样皮肤综合征（SSSS）是一种由某些金黄色葡萄球菌菌株感染引起的皮肤水疱病。体外研究表明，这些细菌分泌的表皮松解毒素可裂解桥粒黏附分子桥粒芯糖蛋白 1，导致表皮浅层细胞间失去接触。在这项研究中，我们研究了 SSSS 患者活检中的桥粒芯糖蛋白 1的命运，以观察桥粒芯糖蛋白 1 的胞外结构域是否被裂解。我们的数据在很大程度上证实了之前的体外数据。不同的活检显示桥粒芯糖蛋白 1 的胞外结构域不同程度地丢失。同时，桥粒芯糖蛋白 1 的胞内结构域仍然存在。最值得注意的是，在我们的一位患者中，免疫荧光分析表明，受影响的不是桥粒芯糖蛋白 1，而是另一种桥粒黏附分子桥粒胶蛋白 1。这就提出了一个问题，即是否有其他毒素和/或除金黄色葡萄球菌以外的其他细菌也可能导致 SSSS。
