Dixit V, Nguyen H, Dixit V M
Varian Sample Preparation Products, Harbor City, CA 90710.
J Chromatogr. 1991 Feb 15;563(2):379-84. doi: 10.1016/0378-4347(91)80045-e.
A rapid, selective, and sensitive method is described for the purification and analysis of fluoxetine and norfluoxetine using a solid-phase extraction column and gas chromatography-electron-capture detection. Linear quantitative response curves for fluoxetine and norfluoxetine are generated over a concentration range of 20-200 ng/ml. Overall extraction efficiency of the extraction procedure is found to be greater than 90% and greater than 75% with correlation coefficients of 0.997 and 0.993 for fluoxetine and norfluoxetine, respectively.
描述了一种快速、选择性和灵敏的方法，用于使用固相萃取柱和气相色谱-电子捕获检测来纯化和分析氟西汀和去甲氟西汀。在20-200 ng/ml的浓度范围内生成了氟西汀和去甲氟西汀的线性定量响应曲线。发现该萃取程序的总体萃取效率分别大于90%和大于75%，氟西汀和去甲氟西汀的相关系数分别为0.997和0.993。
