镍催化的 1,3,4-恶二唑与炔烃和苯乙烯的 C-H 烯基化和烷基化反应。
Nickel-catalyzed C-H alkenylation and alkylation of 1,3,4-oxadiazoles with alkynes and styrenes.
机构信息
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
J Org Chem. 2009 Aug 21;74(16):6410-3. doi: 10.1021/jo901350j.
PMID:20560577
Abstract
The addition reaction of 1,3,4-oxadiazoles to alkynes via C-H bond cleavage efficiently proceeds in the presence of a nickel catalyst. This direct coupling allows a facile access to alkenyl-substituted oxadiazoles. The reaction with styrenes in place of alkynes is also available to selectively afford the corresponding branched adducts.
摘要
1,3,4-恶二唑通过 C-H 键断裂与炔烃的加成反应在镍催化剂的存在下高效进行。这种直接偶联反应为烯基取代的恶二唑提供了一种简便的合成方法。用取代的苯乙烯代替炔烃进行反应，也可以选择性地得到相应的支化加合物。
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