镍和铜催化的在氧气或大气条件下末端炔烃与唑类和多氟芳烃的直接炔基化反应。
Nickel- and copper-catalyzed direct alkynylation of azoles and polyfluoroarenes with terminal alkynes under O(2) or atmospheric conditions.
机构信息
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
Org Lett. 2010 May 21;12(10):2358-61. doi: 10.1021/ol100699g.
PMID:20415435
Abstract
The direct C-H alkynylation of azoles with terminal alkynes proceeds efficiently under a nickel/O(2) catalytic system. On the other hand, a copper/air catalyst enables the coupling of polyfluoroarenes with terminal alkynes. These catalyses provide new accesses to arylacetylenes through the formal direct Sonogashira coupling.
摘要
在镍/氧气催化体系下，唑类化合物与末端炔烃的直接 C-H 炔基化反应高效进行。另一方面，铜/空气催化剂能够实现多氟芳烃与末端炔烃的偶联。这些催化反应通过形式上的直接 Sonogashira 偶联为芳基乙炔的合成提供了新途径。
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