Deutekom Marije, van Rossum Leo G M, van Rijn Anne F, Laheij Robert J F, Fockens Paul, Bossuyt Patrick M M, Dekker Evelien, Jansen Jan B M J
Department of Social Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Scand J Gastroenterol. 2010 Nov;45(11):1345-9. doi: 10.3109/00365521.2010.497937. Epub 2010 Jun 21.
Colorectal cancer (CRC) screening programs can decide upon the type of fecal occult blood test (FOBT): the guaiac FOBT (g-FOBT) or the immunological FOBT (i-FOBT). The effectiveness of any screening program depends not only on the diagnostic performance of the screening test but also on the compliance and general acceptance of the test by the public. Any decision on the type of FOBT for CRC screening should also take acceptation and perception into account. The aim of the present study was to study differences in patient perception between i-FOBT and g-FOBT and differences in perception and participation rates among relevant subgroups in a population based study.
Differences in patient perception of i-FOBT and g-FOBT and differences in perception and participation rates among relevant subgroups were investigated (n = 20,623) by sending a short questionnaire to all invited to the first Dutch CRC screening trial.
i-FOBT was perceived significantly more favorable than g-FOBT. About 1275 (32%) participants reported the g-FOBT not easy to use, not easy to perform, disgusting or shameful compared to 742 (16%) for the i-FOBT (p < 0.001). The participation rate was significantly higher in those who received i-FOBT compared to the g-FOBT group: 6159 of 10,322 (60%) versus 4839 of 10,301 (47%) (p < 0.001).
These findings support the selection of i-FOBT as the more appropriate test for population screening programs.
结直肠癌（CRC）筛查项目需要决定粪便潜血试验（FOBT）的类型：愈创木脂法粪便潜血试验（g-FOBT）或免疫法粪便潜血试验（i-FOBT）。任何筛查项目的有效性不仅取决于筛查试验的诊断性能，还取决于公众对该试验的依从性和普遍接受度。关于用于CRC筛查的FOBT类型的任何决定也应考虑接受度和认知度。本研究的目的是在一项基于人群的研究中，研究i-FOBT和g-FOBT在患者认知方面的差异，以及相关亚组在认知率和参与率方面的差异。
通过向所有受邀参加首次荷兰CRC筛查试验的人发送一份简短问卷，调查i-FOBT和g-FOBT在患者认知方面的差异，以及相关亚组在认知率和参与率方面的差异（n = 20623）。
i-FOBT的认可度明显高于g-FOBT。约1275名（32%）参与者表示g-FOBT使用不便、操作不易、令人厌恶或感到羞耻，而i-FOBT为742名（16%）（p < 0.001）。与g-FOBT组相比，接受i-FOBT的人的参与率明显更高：10322人中的6159人（60%），而10301人中的4839人（47%）（p < 0.001）。
这些发现支持选择i-FOBT作为人群筛查项目中更合适的检测方法。
