日本红枫 Acer pycnanthum 及其成分 Ginnalin B 和 C 的降血糖作用。
Anti-hyperglycaemic effects of the Japanese red maple Acer pycnanthum and its constituents the ginnalins B and C.
机构信息
Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan.
出版信息
J Enzyme Inhib Med Chem. 2011 Apr;26(2):176-80. doi: 10.3109/14756366.2010.486795. Epub 2010 Jun 21.
The anti-hyperglycaemic effects of the leaves of Acer pycnanthum K. Koch, and the purification and identification of the active compounds were investigated. Extracts of the leaves showed a potent inhibitory effect on the α-glucosidase in both in vivo and in vitro experiments. The fractionation of the crude extract gave two active compounds, ginnalin B (6-O-galloyl-1,5-anhydro-D-glucitol) and ginnalin C (2-O-galloyl-1,5-anhydro-D-glucitol), by spectroscopic analysis. This is the first report that A. pycnanthum and its constituents may be useful for the prevention or treatment of diabetes mellitus.
研究了 Acer pycnanthum K. Koch 叶的降血糖作用，以及活性化合物的纯化和鉴定。叶提取物在体内和体外实验中均显示出对 α-葡萄糖苷酶的强烈抑制作用。通过光谱分析，从粗提取物中分离得到两种活性化合物，即 ginnalin B（6-O-没食子酰基-1,5-脱水-D-葡萄糖醇）和 ginnalin C（2-O-没食子酰基-1,5-脱水-D-葡萄糖醇）。这是首次报道 Acer pycnanthum 及其成分可能可用于预防或治疗糖尿病。
Zotero 插件