Clause Kelly C, Liu Li J, Tobita Kimimasa
Cardiovascular Development Research Program, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Cell Commun Adhes. 2010 Apr;17(2):48-54. doi: 10.3109/15419061.2010.492535.
A number of factors contribute to the control of stem cell fate. In particular, the evidence for how physical forces control the stem cell differentiation program is now accruing. In this review, the authors discuss the types of physical forces: mechanical forces, cell shape, extracellular matrix geometry/properties, and cell-cell contacts and morphogenic factors, which evidence suggests play a role in influencing stem cell fate.
许多因素有助于控制干细胞的命运。特别是，关于物理力如何控制干细胞分化程序的证据正在不断积累。在这篇综述中，作者讨论了物理力的类型：机械力、细胞形状、细胞外基质几何形状/特性、细胞间接触和形态发生因子，有证据表明这些因素在影响干细胞命运方面发挥作用。
