Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
Am J Reprod Immunol. 2010 Nov;64(5):333-8. doi: 10.1111/j.1600-0897.2010.00882.x.
To investigate whether the peroxisome proliferator-activated receptor (PPAR)-γ2 Pro12Ala polymorphism is associated with a risk of advanced-stage endometriosis in a Korean population.
Case-control study in a collective of 446 patients and 427 controls. The Pro12Ala polymorphism of PPAR-γ2 gene was genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis.
The distribution of the PPAR-γ2 Pro12Ala polymorphism was different between the advanced-stage endometriosis group and the control group (non-CC rates were 5.2% for patients with advanced endometriosis and 10.1% for the control group, respectively, P = 0.006). The frequency for the Ala-12 allele variant was significantly lower in patients with advanced stage of endometriosis (2.7%) than in the control group (5.3%) (P = 0.006).
These findings suggest that the PPAR-γ2 Pro12Ala polymorphism is associated with advanced-stage endometriosis in the Korean population. Unlike results from other studies reported so far, the Ala-12 allele may have protective effects against advanced-stage endometriosis in the Korean population.
探讨过氧化物酶体增殖物激活受体（PPAR）-γ2 Pro12Ala 多态性是否与韩国人群中晚期子宫内膜异位症的风险相关。
在 446 名患者和 427 名对照者的集合中进行病例对照研究。使用聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）分析对 PPAR-γ2 基因的 Pro12Ala 多态性进行基因分型。
PPAR-γ2 Pro12Ala 多态性在晚期子宫内膜异位症组和对照组之间的分布不同（非 CC 率分别为 5.2%的患者患有晚期子宫内膜异位症和 10.1%的对照组，P=0.006）。Ala-12 等位基因变体在晚期子宫内膜异位症患者中的频率明显低于对照组（2.7%比 5.3%）（P=0.006）。
这些发现表明，PPAR-γ2 Pro12Ala 多态性与韩国人群中晚期子宫内膜异位症有关。与迄今为止报道的其他研究结果不同，Ala-12 等位基因可能对韩国人群中晚期子宫内膜异位症具有保护作用。
