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皮内给药 RiVax 可保护小鼠免受粘膜和全身蓖麻毒素中毒。

Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication.

机构信息

The Cancer Immunobiology Center, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd., Dallas, TX 75390-8576, USA.

出版信息

Vaccine. 2010 Jul 19;28(32):5315-22. doi: 10.1016/j.vaccine.2010.05.045. Epub 2010 Jun 1.

DOI:10.1016/j.vaccine.2010.05.045
PMID:20562013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2908217/
Abstract

Ricin toxin is a CDC level B biothreat. We have developed a ricin vaccine, RiVax, which is a recombinant mutant of ricin A chain. RiVax is safe, immunogenic and protective in mice when administered intramuscularly (IM). We have now attempted to increase the utility and immunogenicity of RiVax by administering it intradermally (ID) with or without alum. Without alum, Rivax administered by the ID and IM routes was equally immunogenic and protective. With alum, ID vaccinations were more immunogenic and protective against both systemic and mucosal challenge with ricin and superior in protecting animals from ricin-induced lung damage.

摘要

蓖麻毒素是疾病预防控制中心生物威胁级别 B 级的物质。我们研发了一种蓖麻疫苗，RiVax，它是蓖麻毒素 A 链的重组突变体。当肌肉内（IM）给药时，RiVax 在小鼠中是安全的、具有免疫原性的并且有保护作用。现在，我们试图通过皮内（ID）途径给予 RiVax 或与明矾联合应用来提高其功效和免疫原性。不使用明矾时，ID 和 IM 途径给予 RiVax 具有同等的免疫原性和保护性。使用明矾时，ID 接种在针对系统性和粘膜性蓖麻毒素挑战时更具免疫原性和保护性，并且在保护动物免受蓖麻毒素引起的肺部损伤方面更具优势。

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本文引用的文献

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Vaccine. 2010 Mar 11;28(12):2428-35. doi: 10.1016/j.vaccine.2009.12.081. Epub 2010 Jan 12.
2
A phase I evaluation of inactivated influenza A/H5N1 vaccine administered by the intradermal or the intramuscular route.皮内或肌内途径接种甲型 H5N1 流感灭活疫苗的 I 期评估。
Vaccine. 2010 Apr 9;28(17):3025-9. doi: 10.1016/j.vaccine.2009.10.152. Epub 2009 Nov 18.
3
Virosomal hepatitis a vaccine: comparing intradermal and subcutaneous with intramuscular administration.
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J Leukoc Biol. 2016 Aug;100(2):361-9. doi: 10.1189/jlb.3A0415-153RR. Epub 2016 Apr 8.
4
Progress and challenges associated with the development of ricin toxin subunit vaccines.蓖麻毒素亚单位疫苗研发的进展与挑战
Expert Rev Vaccines. 2016 Sep;15(9):1213-22. doi: 10.1586/14760584.2016.1168701. Epub 2016 Apr 6.
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J Pharm Sci. 2016 May;105(5):1603-1613. doi: 10.1016/j.xphs.2016.02.009. Epub 2016 Mar 15.
6
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10
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