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1
Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication.皮内给药 RiVax 可保护小鼠免受粘膜和全身蓖麻毒素中毒。
Vaccine. 2010 Jul 19;28(32):5315-22. doi: 10.1016/j.vaccine.2010.05.045. Epub 2010 Jun 1.
2
Durable Immunity to Ricin Toxin Elicited by a Thermostable, Lyophilized Subunit Vaccine.热稳定冻干单价疫苗诱导蓖麻毒素的持久免疫力。
mSphere. 2021 Dec 22;6(6):e0075021. doi: 10.1128/mSphere.00750-21. Epub 2021 Nov 3.
3
RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol.RiVax是一种重组蓖麻毒素亚单位疫苗，可保护小鼠免受经口或气溶胶途径给予的蓖麻毒素侵害。
Vaccine. 2007 Oct 16;25(42):7459-69. doi: 10.1016/j.vaccine.2007.08.018. Epub 2007 Aug 30.
4
A lyophilized formulation of RiVax, a recombinant ricin subunit vaccine, retains immunogenicity.一种利福昔单抗的冻干制剂，一种重组蓖麻毒素亚单位疫苗，保留了免疫原性。
Vaccine. 2010 Mar 11;28(12):2428-35. doi: 10.1016/j.vaccine.2009.12.081. Epub 2010 Jan 12.
5
LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity.LT-IIb(T13I)，一种非毒性 II 型不耐热肠毒素，增强了蓖麻毒素亚单位疫苗引发中和抗体和保护性免疫的能力。
PLoS One. 2013 Aug 2;8(8):e69678. doi: 10.1371/journal.pone.0069678. Print 2013.
6
Comparative efficacy of two leading candidate ricin toxin a subunit vaccines in mice.两种主要候选蓖麻毒素A亚基疫苗在小鼠体内的比较疗效
Clin Vaccine Immunol. 2013 Jun;20(6):789-94. doi: 10.1128/CVI.00098-13. Epub 2013 Mar 20.
7
Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen.单点突变对重组蓖麻毒素 A 链亚单位疫苗抗原稳定性和免疫原性的影响。
Hum Vaccin Immunother. 2013 Apr;9(4):744-52. doi: 10.4161/hv.22998. Epub 2013 Apr 1.
8
Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice.具有增强能力在小鼠中引发毒素中和抗体反应的新型蓖麻毒素亚基抗原。
J Pharm Sci. 2016 May;105(5):1603-1613. doi: 10.1016/j.xphs.2016.02.009. Epub 2016 Mar 15.
9
Alpha-galactosylceramide (αGalCer) enhances vaccine-induced protection in a model of ricin intoxication.α-半乳糖神经酰胺（αGalCer）增强蓖麻毒素中毒模型中的疫苗诱导保护作用。
Hum Vaccin Immunother. 2018;14(8):2053-2057. doi: 10.1080/21645515.2018.1461299. Epub 2018 May 14.
10
Thermal stability and epitope integrity of a lyophilized ricin toxin subunit vaccine.冻干粉化蓖麻毒素毒素亚单位疫苗的热稳定性和抗原表位完整性。
Vaccine. 2018 Sep 25;36(40):5967-5976. doi: 10.1016/j.vaccine.2018.08.059. Epub 2018 Aug 29.

引用本文的文献

1
A New Method for Extraction and Analysis of Ricin Samples through MALDI-TOF-MS/MS.通过 MALDI-TOF-MS/MS 进行蓖麻毒素样本的提取和分析的新方法。
Toxins (Basel). 2019 Apr 3;11(4):201. doi: 10.3390/toxins11040201.
2
Plant Ribosome-Inactivating Proteins: Progesses, Challenges and Biotechnological Applications (and a Few Digressions).植物核糖体失活蛋白：进展、挑战和生物技术应用（及一些题外话）。
Toxins (Basel). 2017 Oct 12;9(10):314. doi: 10.3390/toxins9100314.
3
Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils.II型不耐热肠毒素LT-IIb对体液免疫的增强作用依赖于白细胞介素-6和中性粒细胞。
J Leukoc Biol. 2016 Aug;100(2):361-9. doi: 10.1189/jlb.3A0415-153RR. Epub 2016 Apr 8.
4
Progress and challenges associated with the development of ricin toxin subunit vaccines.蓖麻毒素亚单位疫苗研发的进展与挑战
Expert Rev Vaccines. 2016 Sep;15(9):1213-22. doi: 10.1586/14760584.2016.1168701. Epub 2016 Apr 6.
5
Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice.具有增强能力在小鼠中引发毒素中和抗体反应的新型蓖麻毒素亚基抗原。
J Pharm Sci. 2016 May;105(5):1603-1613. doi: 10.1016/j.xphs.2016.02.009. Epub 2016 Mar 15.
6
Recent advances in the development of vaccines against ricin.抗蓖麻毒素疫苗研发的最新进展
Hum Vaccin Immunother. 2016 May 3;12(5):1196-201. doi: 10.1080/21645515.2015.1124202. Epub 2016 Jan 25.
7
Strong protection against ricin challenge induced by a novel modified ricin A-chain protein in mouse model.新型修饰蓖麻毒素A链蛋白在小鼠模型中对蓖麻毒素攻击具有强大的保护作用。
Hum Vaccin Immunother. 2015;11(7):1779-87. doi: 10.1080/21645515.2015.1038446.
8
Differential neutralizing activities of a single domain camelid antibody (VHH) specific for ricin toxin's binding subunit (RTB).针对蓖麻毒素结合亚基（RTB）的单域骆驼抗体（VHH）的差异中和活性。
PLoS One. 2014 Jun 11;9(6):e99788. doi: 10.1371/journal.pone.0099788. eCollection 2014.
9
Near-infrared laser adjuvant for influenza vaccine.用于流感疫苗的近红外激光佐剂
PLoS One. 2013 Dec 11;8(12):e82899. doi: 10.1371/journal.pone.0082899. eCollection 2013.
10
LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity.LT-IIb(T13I)，一种非毒性 II 型不耐热肠毒素，增强了蓖麻毒素亚单位疫苗引发中和抗体和保护性免疫的能力。
PLoS One. 2013 Aug 2;8(8):e69678. doi: 10.1371/journal.pone.0069678. Print 2013.

本文引用的文献

1
A lyophilized formulation of RiVax, a recombinant ricin subunit vaccine, retains immunogenicity.一种利福昔单抗的冻干制剂，一种重组蓖麻毒素亚单位疫苗，保留了免疫原性。
Vaccine. 2010 Mar 11;28(12):2428-35. doi: 10.1016/j.vaccine.2009.12.081. Epub 2010 Jan 12.
2
A phase I evaluation of inactivated influenza A/H5N1 vaccine administered by the intradermal or the intramuscular route.皮内或肌内途径接种甲型 H5N1 流感灭活疫苗的 I 期评估。
Vaccine. 2010 Apr 9;28(17):3025-9. doi: 10.1016/j.vaccine.2009.10.152. Epub 2009 Nov 18.
3
Virosomal hepatitis a vaccine: comparing intradermal and subcutaneous with intramuscular administration.甲型肝炎病毒疫苗：皮内和皮下与肌肉注射的比较。
J Travel Med. 2009 Nov-Dec;16(6):413-9. doi: 10.1111/j.1708-8305.2009.00351.x.
4
Intradermal influenza vaccine for older adults: a randomized controlled multicenter phase III study.老年人皮内流感疫苗：一项随机对照多中心 III 期研究。
Vaccine. 2009 Dec 9;27(52):7304-12. doi: 10.1016/j.vaccine.2009.10.033. Epub 2009 Oct 20.
5
Mechanism of action of clinically approved adjuvants.临床批准佐剂的作用机制。
Curr Opin Immunol. 2009 Feb;21(1):23-9. doi: 10.1016/j.coi.2009.01.004. Epub 2009 Feb 24.
6
Activation of the cholinergic antiinflammatory pathway reduces ricin-induced mortality and organ failure in mice.胆碱能抗炎通路的激活可降低蓖麻毒素诱导的小鼠死亡率和器官衰竭。
Mol Med. 2009 May-Jun;15(5-6):166-72. doi: 10.2119/molmed.2008.00105. Epub 2009 Feb 5.
7
Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells.人类表皮朗格汉斯细胞和CD14+真皮树突状细胞的功能特化
Immunity. 2008 Sep 19;29(3):497-510. doi: 10.1016/j.immuni.2008.07.013.
8
Post-exposure targeting of specific epitopes on ricin toxin abrogates toxin-induced hypoglycemia, hepatic injury, and lethality in a mouse model.在小鼠模型中，暴露后靶向蓖麻毒素上的特定表位可消除毒素诱导的低血糖、肝损伤和致死性。
Lab Invest. 2008 Nov;88(11):1178-91. doi: 10.1038/labinvest.2008.83. Epub 2008 Sep 8.
9
Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk.前沿：肠系膜淋巴结中的朗格汉斯细胞+树突状细胞为皮肤和肠道免疫系统的相互作用奠定了基础。
J Immunol. 2008 Apr 1;180(7):4361-5. doi: 10.4049/jimmunol.180.7.4361.
10
RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol.RiVax是一种重组蓖麻毒素亚单位疫苗，可保护小鼠免受经口或气溶胶途径给予的蓖麻毒素侵害。
Vaccine. 2007 Oct 16;25(42):7459-69. doi: 10.1016/j.vaccine.2007.08.018. Epub 2007 Aug 30.

皮内给药 RiVax 可保护小鼠免受粘膜和全身蓖麻毒素中毒。

Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication.

机构信息

The Cancer Immunobiology Center, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd., Dallas, TX 75390-8576, USA.

出版信息

Vaccine. 2010 Jul 19;28(32):5315-22. doi: 10.1016/j.vaccine.2010.05.045. Epub 2010 Jun 1.

DOI:10.1016/j.vaccine.2010.05.045
PMID:20562013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2908217/
Abstract

Ricin toxin is a CDC level B biothreat. We have developed a ricin vaccine, RiVax, which is a recombinant mutant of ricin A chain. RiVax is safe, immunogenic and protective in mice when administered intramuscularly (IM). We have now attempted to increase the utility and immunogenicity of RiVax by administering it intradermally (ID) with or without alum. Without alum, Rivax administered by the ID and IM routes was equally immunogenic and protective. With alum, ID vaccinations were more immunogenic and protective against both systemic and mucosal challenge with ricin and superior in protecting animals from ricin-induced lung damage.

摘要

蓖麻毒素是疾病预防控制中心生物威胁级别 B 级的物质。我们研发了一种蓖麻疫苗，RiVax，它是蓖麻毒素 A 链的重组突变体。当肌肉内（IM）给药时，RiVax 在小鼠中是安全的、具有免疫原性的并且有保护作用。现在，我们试图通过皮内（ID）途径给予 RiVax 或与明矾联合应用来提高其功效和免疫原性。不使用明矾时，ID 和 IM 途径给予 RiVax 具有同等的免疫原性和保护性。使用明矾时，ID 接种在针对系统性和粘膜性蓖麻毒素挑战时更具免疫原性和保护性，并且在保护动物免受蓖麻毒素引起的肺部损伤方面更具优势。