MC4R 基因多态性与牛经济性状的相关性。
Polymorphisms in MC4R gene and correlations with economic traits in cattle.
机构信息
College of Animal Science and Technology, Northwest A & F University, Yangling, China.
出版信息
Mol Biol Rep. 2010 Dec;37(8):3941-4. doi: 10.1007/s11033-010-0051-0. Epub 2010 Jun 19.
MC4R contributes to the control of food intake and energy expenditure, and single nucleotide polymorphisms (SNPs) in the MC4R gene have clearly been associated with backfat depth, feed intake and growth rate in pig. Our objectives were to scan the complete coding region by sequencing in samples from eight cattle breeds, to estimate the frequency of the SNPs in the MC4R gene and to determine if individual genotypes were associated with several economic traits. Five polymorphisms were detected at position 19 (C/A), 20 (A/T), 83(T/C), 128 (G/A), and 1069 (G/C), and the last one was significantly associated with backfat thickness value (P < 0.01, n = 245). The linkage disequilibrium analysis indicated that the SNP markers C19A, A20T, T83C and G128A were completely linked (r (2) = 1).
MC4R 参与食物摄入和能量消耗的控制，MC4R 基因中的单核苷酸多态性 (SNP) 显然与猪的背膘厚度、采食量和生长速度有关。我们的目的是在来自 8 个牛品种的样本中通过测序扫描完整的编码区，估计 MC4R 基因中 SNP 的频率，并确定个体基因型是否与多个经济性状相关。在位置 19 (C/A)、20 (A/T)、83 (T/C)、128 (G/A) 和 1069 (G/C) 处检测到 5 个多态性，最后一个与背膘厚度值显著相关 (P < 0.01，n = 245)。连锁不平衡分析表明，SNP 标记 C19A、A20T、T83C 和 G128A 完全连锁 (r (2) = 1)。
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