Phytother Res. 2010 Nov;24(11):1734-8. doi: 10.1002/ptr.3212.
The aim of the present study was to investigate the effect of an antidiabetic polysaccharide (IJP) from Inula japonica on gastrointestinal transit in normal mice and on constipation in two models of constipated mice.
Two models of constipation in mice were respectively induced by fasted water for 4 days or induced by diphenoxylate. The normal and constipated mice were administered IJP once at doses of 100 and 400 mg/kg (p.o.), the gastrointestinal vermicular motion, start time of defecation, number and weight of stool were investigated.
After administration of IJP, the gastrointestinal propulsive rate was increased by 9.79% and 10.42%, the start time of defecation was shortened by 37.27% and 44.06%, the number of feces increased by 115.4% and 130.8% in normal mice. In fasting-water constipated mice, the start time of defecation was shortened by 9.69% and 30.52% by IJP, defecation granules raised by 22.09% and 39.53%, wet feces weights were increased by 23.50% and 39.14% compared with the untreated constipated mice. In diphenoxylate-induced mice, the start time of defecation was shortened by 25.48% and 28.13%, defecation granules raised by 100.0% and 118.0%.
Consumption of IJP effectively improved bowel movement, stool output observed in this study. IJP may be practical in relieving constipation in the elderly diabetic population.
本研究旨在探讨旋覆花中一种具有降血糖作用的多糖（IJP）对正常小鼠胃肠转运功能的影响及其对两种便秘模型小鼠便秘的作用。
分别采用禁食水 4 天和给予地芬诺酯制备便秘模型，正常及便秘模型小鼠单次灌胃给予 IJP100 和 400mg/kg，观察胃肠蠕动推进率、首次排便时间、排便粒数和粪便重量。
IJP 给药后可分别使正常小鼠的胃肠推进率增加 9.79%和 10.42%，首次排便时间缩短 37.27%和 44.06%，排便粒数增加 115.4%和 130.8%；对禁食水所致便秘模型小鼠，IJP 可使首次排便时间分别缩短 9.69%和 30.52%，排便粒数增加 22.09%和 39.53%，湿粪重量增加 23.50%和 39.14%；对地芬诺酯所致便秘模型小鼠，IJP 可使首次排便时间分别缩短 25.48%和 28.13%，排便粒数增加 100.0%和 118.0%。
IJP 可有效改善便秘小鼠的排便情况，提示其对便秘有一定的缓解作用，有望用于治疗老年糖尿病患者的便秘。
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