Department of Natural Products, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab 160 062, India.
Phytother Res. 2010 Oct;24(10):1562-6. doi: 10.1002/ptr.3218.
Chlorophytum arundinaceum, Asparagus adscendens and Asparagus racemosus are used in the Indian traditional system of medicine for improving the general state of health and for stress-related immune disorders. The effects of the methanol and aqueous extracts of the tuberous roots of these plants were examined in an experimental mouse model of stress, induced by swimming. The extracts were shown to exert an inhibitory effect on pro-inflammatory cytokines, namely interleukin 1β and tumour necrosis factor α, and on the production of nitric oxide in mouse macrophage cells RAW 264.7 stimulated by lipopolysaccharide in vitro. Similar inhibition was also observed in the production of interleukin 2 in EL 4 lymphoma cells stimulated by concanavalin A. Corticosterone levels in serum and adrenal glands were measured. The findings suggest that these plants may be beneficial in the management of stress and inflammatory conditions.
吊兰、天门冬和麦门冬在印度传统医学中被用于改善整体健康状况和与应激相关的免疫紊乱。研究了这些植物块根的甲醇和水提取物在游泳诱导的应激实验小鼠模型中的作用。结果表明，这些提取物对促炎细胞因子白细胞介素 1β和肿瘤坏死因子 α以及脂多糖体外刺激的小鼠巨噬细胞 RAW 264.7 中一氧化氮的产生具有抑制作用。在刀豆蛋白 A 刺激的 EL-4 淋巴瘤细胞中白细胞介素 2 的产生也观察到类似的抑制作用。测量了血清和肾上腺中的皮质酮水平。研究结果表明，这些植物可能有益于应激和炎症状况的管理。
