Joshi Tanuj, Sah Sangeeta P, Singh Anita
Department of Pharmaceutical Sciences, Bhimtal Campus, Kumaun University, Nainital 263 136, India.
Indian J Exp Biol. 2012 Jun;50(6):419-24.
Ethanolic extract of the roots of A. racemosus improved the stress tolerance in chemical writhing test and swimming endurance test at all the doses as compared to stress control group. Restraint stress induced elevation of blood glucose, triglyceride and cholesterol levels were significantly lowered by pretreatment with extract. Moreover, stress induced variations in levels of lipid peroxidation, nitric oxide, protein and glutathione content in mouse brain were significantly ameliorated by pretreatment with extract. The extract attenuated the elevated weight of adrenal glands and increased the reduced weight of the spleen during stress. In conclusion, the results suggest antistress property of Asparagus racemosus in different model of stress.
与应激对照组相比，总状天门冬根的乙醇提取物在所有剂量下均能提高化学性扭体试验和游泳耐力试验中的应激耐受性。提取物预处理可显著降低束缚应激诱导的血糖、甘油三酯和胆固醇水平升高。此外，提取物预处理可显著改善应激诱导的小鼠大脑脂质过氧化、一氧化氮、蛋白质和谷胱甘肽含量的变化。提取物可减轻应激期间肾上腺重量的增加，并增加脾脏重量的减轻。总之，结果表明总状天门冬在不同应激模型中具有抗应激特性。
